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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H23N5O2S2.ClH
Molecular Weight 526.073
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BMS-214662 HYDROCHLORIDE

SMILES

Cl.O=S(=O)(N1CC2=C(C=CC(=C2)C#N)N(CC3=CN=CN3)C[C@H]1CC4=CC=CC=C4)C5=CC=CS5

InChI

InChIKey=LBPFLNDUCNNGPS-GNAFDRTKSA-N
InChI=1S/C25H23N5O2S2.ClH/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22;/h1-11,14,18,23H,12,15-17H2,(H,27,28);1H/t23-;/m1./s1

HIDE SMILES / InChI
Bristol-Myers Squibb developed BMS-214662 as potent and selective farnesyl transferase inhibitor with potent antitumor activity. BMS-214662 participated in phase II trials in the US for pancreatic, head and neck, lung and colorectal cancers. However, further information is not available.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.7 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors.
2010 Sep
Patents

Patents

Sample Use Guides

Patients were treated every week as tolerated with i.v. paclitaxel (fixed dose, 80 mg/m(2)/wk) administered over 1 h followed by i.v. BMS-214662 (escalating doses, 80-245 mg/m(2)/wk) over 1 h starting 30 min after completion of paclitaxel.
Route of Administration: Intravenous
Name Type Language
BMS-214662 HYDROCHLORIDE
Common Name English
1H-1,4-BENZODIAZEPINE-7-CARBONITRILE, 2,3,4,5-TETRAHYDRO-1-(1H-IMIDAZOL-5-YLMETHYL)-3-(PHENYLMETHYL)-4-(2-THIENYLSULFONYL)-, HYDROCHLORIDE (1:1), (3R)-
Systematic Name English
Code System Code Type Description
PUBCHEM
44189294
Created by admin on Sat Dec 16 08:18:27 GMT 2023 , Edited by admin on Sat Dec 16 08:18:27 GMT 2023
PRIMARY
FDA UNII
2ZRT8VWQ9J
Created by admin on Sat Dec 16 08:18:27 GMT 2023 , Edited by admin on Sat Dec 16 08:18:27 GMT 2023
PRIMARY
CAS
195981-08-9
Created by admin on Sat Dec 16 08:18:27 GMT 2023 , Edited by admin on Sat Dec 16 08:18:27 GMT 2023
PRIMARY
DRUG BANK
DBSALT002163
Created by admin on Sat Dec 16 08:18:27 GMT 2023 , Edited by admin on Sat Dec 16 08:18:27 GMT 2023
PRIMARY