U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Insulin glargine, a long-acting form of insulin, was marketed under the brand name LANTUS. Lantus is indicated for the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia. The primary activity of insulin glargine is regulation of glucose metabolism. It lowers blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. The off-label use of insulin glargine is the treatment type 2 diabetes in children and the treatment of gestational diabetes.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P06213
Gene ID: 3643.0
Gene Symbol: INSR
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LANTUS

Approved Use

LANTUS is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.

Launch Date

2000
Primary
LANTUS

Approved Use

LANTUS is indicated for once-daily subcutaneous administration at bedtime in the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.

Launch Date

2000
PubMed

PubMed

TitleDatePubMed
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling.
2010 Aug
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel.
2014 Apr

Sample Use Guides

LANTUS (Insulin glargine) should be administered subcutaneously once a day at bedtime. LANTUS is not intended for intravenous administration.
Route of Administration: Other
Name Type Language
INSULIN GLARGINE
EMA EPAR   INN   MI   USAN   USP-RS   WHO-DD  
USAN   INN  
Official Name English
Insulin glargine [WHO-DD]
Common Name English
INSULIN GLARGINE [EMA EPAR]
Common Name English
INSULIN,GLARGINE,HUMAN/RDNA [VANDF]
Common Name English
TOUJEO SOLOSTAR
Brand Name English
INSULIN GLARGINE RECOMBINANT [ORANGE BOOK]
Common Name English
BASAGLAR COMPONENT INSULIN GLARGINE
Brand Name English
INSULIN (HUMAN), 21A-GLYCINE-30BA-L-ARGININE-30BB-L-ARGININE-
Common Name English
LANTUS R
Brand Name English
INSULIN GLARGINE COMPONENT OF SOLIQUA 100/33
Brand Name English
GLARGIN
Common Name English
HOE901
Code English
INSULIN,GLARGINE,HUMAN/RDNA
VANDF  
Common Name English
INSULIN GLARGINE COMPONENT OF BASAGLAR
Brand Name English
insulin glargine [INN]
Common Name English
INSULIN GLARGINE [USAN]
Common Name English
LUSDUNA
Brand Name English
INSULIN GLARGINE [JAN]
Common Name English
HOE-71GT
Code English
INSULIN GLARGINE [USP-RS]
Common Name English
HOE-901
Code English
INSULIN (A20A-GLYCINE,B30A-ARGININE,B30B-ARGININE) (HUMAN)
Common Name English
LY-2963016
Code English
LY2963016
Code English
SOLIQUA 100/33 COMPONENT INSULIN GLARGINE
Brand Name English
GLARGINE
Common Name English
INSULIN GLARGINE [MI]
Common Name English
INSULIN GLARGINE [USP MONOGRAPH]
Common Name English
MK-1293
Code English
INSULIN GLARGINE RECOMBINANT
ORANGE BOOK  
Common Name English
HOE 71GT
Code English
INSULIN GLARGINE [EP MONOGRAPH]
Common Name English
INSULIN (A21-GLYCINE,B31-ARGININE,B32-ARGININE) (HUMAN)
Common Name English
LANTUS
Brand Name English
BASAGLAR
Brand Name English
Classification Tree Code System Code
NDF-RT N0000175453
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
WHO-ATC A10AE54
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
WHO-ATC A10AE04
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
WHO-VATC QA10AE04
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
Code System Code Type Description
SMS_ID
100000085460
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PRIMARY
MESH
C106526
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PRIMARY
EPA CompTox
DTXSID0043927
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
PRIMARY
WIKIPEDIA
INSULIN GLARGINE
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
PRIMARY
EVMPD
SUB08196MIG
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PRIMARY
DAILYMED
2ZM8CX04RZ
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PRIMARY
RS_ITEM_NUM
1342059
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PRIMARY
FDA UNII
2ZM8CX04RZ
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PRIMARY
USAN
LL-87
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
PRIMARY
IUPHAR
7572
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PRIMARY
INN
7548
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PRIMARY
CAS
160337-95-1
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PRIMARY
RXCUI
274783
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PRIMARY RxNorm
DRUG CENTRAL
4901
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PRIMARY
ChEMBL
CHEMBL1201497
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PRIMARY
MERCK INDEX
m6297
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PRIMARY Merck Index
PUBCHEM
118984454
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
PRIMARY
NCI_THESAURUS
C47564
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PRIMARY
DRUG BANK
DB00047
Created by admin on Sat Dec 16 10:30:28 GMT 2023 , Edited by admin on Sat Dec 16 10:30:28 GMT 2023
PRIMARY