INSULIN GLARGINE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21081lbl.pdf | http://endocrine-system.emedtv.com/insulin-glargine/what-is-insulin-glargine-used-for-p3.html

Insulin glargine, a long-acting form of insulin, was marketed under the brand name LANTUS. Lantus is indicated for the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia. The primary activity of insulin glargine is regulation of glucose metabolism. It lowers blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. The off-label use of insulin glargine is the treatment type 2 diabetes in children and the treatment of gestational diabetes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Insulin receptor 13 Target ID: P06213 Gene ID: 3643.0 Gene Symbol: INSR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18585815	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
type 1 diabetes mellitus 1 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21081lbl.pdf	Primary		Approved 8429	LANTUS Approved Use LANTUS is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. Launch Date 2000
type 2 diabetes mellitus 5 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21081lbl.pdf	Primary		Approved 8429	LANTUS Approved Use LANTUS is indicated for once-daily subcutaneous administration at bedtime in the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia. Launch Date 2000

PubMed

Title	Date	PubMed
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling.	2010 Aug	20424816
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel.	2014 Apr	24464500

Sample Use Guides

In Vivo Use Guide

LANTUS (Insulin glargine) should be administered subcutaneously once a day at bedtime. LANTUS is not intended for intravenous administration.

Route of Administration: Other

Name

Type

Language

INSULIN GLARGINE

Official Name

English

Insulin glargine [WHO-DD]

Common Name

English

INSULIN GLARGINE [EMA EPAR]

Common Name

English

INSULIN,GLARGINE,HUMAN/RDNA [VANDF]

Common Name

English

TOUJEO SOLOSTAR

Brand Name

English

INSULIN GLARGINE RECOMBINANT [ORANGE BOOK]

Common Name

English

BASAGLAR COMPONENT INSULIN GLARGINE

Brand Name

English

INSULIN (HUMAN), 21A-GLYCINE-30BA-L-ARGININE-30BB-L-ARGININE-

Common Name

English

LANTUS R

Brand Name

English

INSULIN GLARGINE COMPONENT OF SOLIQUA 100/33

Brand Name

English

GLARGIN

Common Name

English

HOE901

Code

English

INSULIN,GLARGINE,HUMAN/RDNA

Common Name

English

INSULIN GLARGINE COMPONENT OF BASAGLAR

Brand Name

English

insulin glargine [INN]

Common Name

English

INSULIN GLARGINE [USAN]

Common Name

English

LUSDUNA

Brand Name

English

INSULIN GLARGINE [JAN]

Common Name

English

HOE-71GT

Code

English

INSULIN GLARGINE [USP-RS]

Common Name

English

HOE-901

Code

English

INSULIN (A20A-GLYCINE,B30A-ARGININE,B30B-ARGININE) (HUMAN)

Common Name

English

LY-2963016

Code

English

LY2963016

Code

English

SOLIQUA 100/33 COMPONENT INSULIN GLARGINE

Brand Name

English

GLARGINE

Common Name

English

INSULIN GLARGINE [MI]

Common Name

English

INSULIN GLARGINE [USP MONOGRAPH]

Common Name

English

MK-1293

Code

English

INSULIN GLARGINE RECOMBINANT

Common Name

English

HOE 71GT

Code

English

INSULIN GLARGINE [EP MONOGRAPH]

Common Name

English

INSULIN (A21-GLYCINE,B31-ARGININE,B32-ARGININE) (HUMAN)

Common Name

English

LANTUS

Brand Name

English

BASAGLAR

Brand Name

English

Classification Tree Code System Code

NDF-RT

N0000175453