DAPANSUTRILE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H7NO2S
Molecular Weight	133.169
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(=O)(=O)CCC#N

InChI

InChIKey=LQFRYKBDZNPJSW-UHFFFAOYSA-N

InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30747785 | https://www.ncbi.nlm.nih.gov/pubmed/30075804 | https://ard.bmj.com/content/78/Suppl_1/A70 | http://www.olatec.com/lead-compound.html

Dapansutrile is an inhibitor of the NLRP3 inflammasome, developed by Olatec Therapeutics LLC. NLRP3 inflammasome is a driver of sterile inflammation in response to myocardial ischemia-reperfusion and other inflammatory conditions. Dapansutrile limits infarct size and prevents left ventricular systolic dysfunction in the mouse model of ischemia-reperfusion injury and suppresses joint inflammation in the mouse model of acute arthritis. Dapansutrile demonstrated a clinical and inflammatory cytokine response in a clinical trial for the treatment of acute gout and is being investigated for the treatment of Systolic Heart Failure and Schnitzler Syndrome.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Interleukin-1 beta 22 Target ID: CHEMBL1909490 Sources: https://adisinsight.springer.com/drugs/800036472\|http://www.olatec.com/science.html	Modulator 828
inflammasome complex 2 Target ID: GO:0061702 Sources: https://adisinsight.springer.com/drugs/800036472	Inhibitor 8297

Name

Type

Language

DAPANSUTRILE

Official Name

English

OLT1177

Code

English

PROPANENITRILE, 3-(METHYLSULFONYL)-

Systematic Name

English

3-METHYLSULFONYLPROPIONITRILE

Systematic Name

English

DAPANSUTRILE [USAN]

Common Name

English

Dapansutrile [WHO-DD]

Common Name

English

dapansutrile [INN]

Common Name

English

OLT-1177

Code

English

Code System Code Type Description

CAS

54863-37-5