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Details

Stereochemistry ACHIRAL
Molecular Formula C17H17N5O
Molecular Weight 307.3498
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LY-2183240

SMILES

CN(C)C(=O)N1N=NN=C1CC2=CC=C(C=C2)C3=CC=CC=C3

InChI

InChIKey=GZNIYOXWFCDBBJ-UHFFFAOYSA-N
InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
12.0 nM [IC50]
54.4 nM [IC50]
Name Type Language
LY-2183240
Common Name English
5-(BIPHENYL-4-YLMETHYL)-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
Systematic Name English
1H-TETRAZOLE-1-CARBOXAMIDE, 5-((1,1'-BIPHENYL)-4-YLMETHYL)-N,N-DIMETHYL-
Systematic Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-LY-2183240
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
Code System Code Type Description
WIKIPEDIA
LY-2183240
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
PRIMARY LY-2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide and as an inhibitor of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce both analgesic and anxiolytic effects in animal models. While LY-2183240 is a potent inhibitor of FAAH, it has relatively poor selectivity and also inhibits several other enzyme side targets. Consequently, it was never developed for clinical use, though it remains widely used in research, and has also been sold as a designer drug.
CAS
874902-19-9
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
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EPA CompTox
DTXSID001024706
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
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PUBCHEM
11507802
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
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FDA UNII
2WBU91OKM7
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
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MANUFACTURER PRODUCT INFORMATION
LY-2183240
Created by admin on Sat Dec 16 10:20:50 GMT 2023 , Edited by admin on Sat Dec 16 10:20:50 GMT 2023
PRIMARY Novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.