LY-2183240

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17N5O
Molecular Weight	307.3498
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(C)C(=O)N1N=NN=C1CC2=CC=C(C=C2)C3=CC=CC=C3

InChI

InChIKey=GZNIYOXWFCDBBJ-UHFFFAOYSA-N

InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 27	Inhibitor 8,504		12.0 nM [IC50]
Monoglyceride lipase 8	Inhibitor 8,504		54.4 nM [IC50]

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Name

Type

Language

LY-2183240

Common Name

English

1H-TETRAZOLE-1-CARBOXAMIDE, 5-((1,1'-BIPHENYL)-4-YLMETHYL)-N,N-DIMETHYL-

Preferred Name

English

5-(BIPHENYL-4-YLMETHYL)-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

Systematic Name

English

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Classification Tree

Code System

Code

Synthetic cannabinoids

WIKIPEDIA

Designer-drugs-LY-2183240

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Code System

Code

Type

Description

WIKIPEDIA

LY-2183240

PRIMARY

LY-2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide and as an inhibitor of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce both analgesic and anxiolytic effects in animal models. While LY-2183240 is a potent inhibitor of FAAH, it has relatively poor selectivity and also inhibits several other enzyme side targets. Consequently, it was never developed for clinical use, though it remains widely used in research, and has also been sold as a designer drug.

CAS

874902-19-9

PRIMARY

EPA CompTox

DTXSID001024706

PRIMARY

PUBCHEM

11507802

PRIMARY

FDA UNII

2WBU91OKM7

PRIMARY

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ACTIVE MOIETY


					2WBU91OKM7

LY-2183240