FLOVAGATRAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H36BN3O7
Molecular Weight	525.402
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)B(O)O

InChI

InChIKey=PAOGOXGDGABPSC-SGNDLWITSA-N

InChI=1S/C27H36BN3O7/c1-37-17-9-15-24(28(35)36)30-25(32)23-14-8-16-31(23)26(33)22(18-20-10-4-2-5-11-20)29-27(34)38-19-21-12-6-3-7-13-21/h2-7,10-13,22-24,35-36H,8-9,14-19H2,1H3,(H,29,34)(H,30,32)/t22-,23+,24+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67532470 | https://www.ncbi.nlm.nih.gov/pubmed/21045018 | https://adisinsight.springer.com/drugs/800020578

FLOVAGATRAN is a potent, reversible, low-molecular-weight, highly selective synthetic direct thrombin inhibitor that has demonstrated promising pharmacokinetic properties and biological activity in preclinical studies. However, its development for thrombosis was discontinued in Phase II.

Originator

Approval Year

PubMed

Title	Date	PubMed

Name

Type

Language

FLOVAGATRAN

Official Name

English

(1R)-1-(N-((BENZYLOXY)CARBONYL)-D-PHENYLALANYL-L-PROLINAMIDO)BUTYLBORONIC ACID

Systematic Name

English

flovagatran [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29750