Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H16N2O3S.H2O |
| Molecular Weight | 274.337 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.CC1=CC=C(N2CCNCC2)C(=C1)S(O)(=O)=O
InChI
InChIKey=ZRQKZWAOIRVBFD-UHFFFAOYSA-N
InChI=1S/C11H16N2O3S.H2O/c1-9-2-3-10(11(8-9)17(14,15)16)13-6-4-12-5-7-13;/h2-3,8,12H,4-7H2,1H3,(H,14,15,16);1H2
Caldaret is intracardiac calcium (Ca2+) handling modulator whose cardioprotective actions are presumed to be due to inhibition of the NCX exchanger and increasing the uptake of Ca2+ via the sarcoplasmic reticulum (SR). Unfortunately, Caldaret failed to demonstrate efficacy in Phase II clinical trials as an adjunct to standard therapy with primary percutaneous coronary intervention patients diagnosed as having an acute myocardial infarction
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of caldaret on the incidence of severe left ventricular dysfunction in patients with ST-elevation myocardial infarction undergoing primary coronary intervention. | 2009-01-01 |
|
| Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. | 2007-02 |
|
| Results of the first clinical study of adjunctive CAldaret (MCC-135) in patients undergoing primary percutaneous coronary intervention for ST-Elevation Myocardial Infarction: the randomized multicentre CASTEMI study. | 2006-11 |
|
| A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design. | 2004-06 |
|
| Breast-feeding may reduce later blood pressure. | 2004-03-16 |
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DTXSID20431256
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DBSALT002435
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192509-24-3
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2SH110E854
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9816981
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ACTIVE MOIETY
SUBSTANCE RECORD
