Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H15N2O4PS.BrH |
| Molecular Weight | 383.199 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.CC(C)CC1=C(N=C(N)S1)C2=CC=C(O2)P(O)(O)=O
InChI
InChIKey=MKDPXWINJXJYOJ-UHFFFAOYSA-N
InChI=1S/C11H15N2O4PS.BrH/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16;/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16);1H
Managlinat dialanetil (MB06322 or CS-917) is an inhibitor of fructose 1,6-bisphphosphatase.
Managlinat dialanetil is a bisamidate prodrug and its activation requires a two-step enzyme catalyzed reaction. Metabasis Therapeutics Inc in collaboration with Daiichi Sankyo Co Ltd was developing managlinat dialanetil for the potential treatment of type 2 diabetes.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. | 2010-10 |
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| Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats. | 2009-11-25 |
|
| CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats. | 2008-12-28 |
|
| Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. | 2007-10 |
|
| Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. | 2006-06 |
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261365-09-7
Created by
admin on Mon Mar 31 23:27:12 GMT 2025 , Edited by admin on Mon Mar 31 23:27:12 GMT 2025
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156613512
Created by
admin on Mon Mar 31 23:27:12 GMT 2025 , Edited by admin on Mon Mar 31 23:27:12 GMT 2025
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2RGC6XUB92
Created by
admin on Mon Mar 31 23:27:12 GMT 2025 , Edited by admin on Mon Mar 31 23:27:12 GMT 2025
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ACTIVE MOIETY
SUBSTANCE RECORD
