Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H20ClNO6S |
Molecular Weight | 425.883 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ONC(=O)C3(CS(=O)(=O)C1=CC=C(OC2=CC=C(Cl)C=C2)C=C1)CCOCC3
InChI
InChIKey=ROSNVSQTEGHUKU-UHFFFAOYSA-N
InChI=1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
CTS-1027 (Ro-1130830) is a hydroxamic acid matrix metalloprotease (MMP) inhibitor. CTS-1027 was originally designed as a strong inhibitor of MMP-2, -3, -8, -9, -12, -13 and -14, without inhibiting MMP-1 and MMP-7. CTS-1027 was proved to be safe in clinical trials for osteoarthritis conducted by Roche. CTS-1027 was then licensed from Roche to Conatus Pharmaceuticals and was investigated as a protector from liver fibrosis in hepatitis C virus patients. The development of the drug was discontinued due to laboratory abnormalities and adverse events in a subset of clinical trial participants.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL333 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10669559 |
0.22 nM [Ki] | ||
Target ID: CHEMBL283 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10669559 |
9.3 nM [Ki] | ||
Target ID: CHEMBL321 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10669559 |
0.58 nM [Ki] | ||
Target ID: CHEMBL280 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10669559 |
0.52 nM [Ki] |
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
FDA ORPHAN DRUG |
258308
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2QD3F58224
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
3342298
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
DB08490
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
100000175619
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
193022-04-7
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
SUB190088
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY | |||
|
DTXSID90172907
Created by
admin on Fri Dec 15 15:45:49 GMT 2023 , Edited by admin on Fri Dec 15 15:45:49 GMT 2023
|
PRIMARY |
ACTIVE MOIETY