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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H35N5.2Cl.Mn
Molecular Weight 483.38
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMISOPASEM MANGANESE

SMILES

[Cl-].[Cl-].[Mn++].C1CC[C@H]2NCC3=CC=CC(CN[C@@H]4CCCC[C@H]4NCCN[C@@H]2C1)=N3

InChI

InChIKey=WXEMWBBXVXHEPU-XNPJUPKFSA-L
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1

HIDE SMILES / InChI

Description

Imisopasem Manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and radioprotective activities. Metaphore Pharmaceuticals Inc. is developing Imisopasem Manganese for the potential treatment of pain, dermatological disease and inflammation. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
single doses of 0.0625, 0.125, and 0.25 mg/kg
Route of Administration: Oral