Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H35N5.2Cl.Mn |
| Molecular Weight | 483.38 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].[Mn++].C1CC[C@H]2NCC3=CC=CC(CN[C@@H]4CCCC[C@H]4NCCN[C@@H]2C1)=N3
InChI
InChIKey=WXEMWBBXVXHEPU-XNPJUPKFSA-L
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1
Imisopasem Manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and radioprotective activities. Metaphore Pharmaceuticals Inc. is developing Imisopasem Manganese for the potential treatment of pain, dermatological disease and inflammation. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. | 2001 Feb |
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| A role for superoxide in gentamicin-mediated nephropathy in rats. | 2002 Aug 16 |
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| Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. | 2003 Jul |
Patents
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NCI_THESAURUS |
C275
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PARENT (SALT/SOLVATE)
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
