U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Icodextrin is a colloid osmotic agent, derived from maltodextrin, used in form of an aqueous solution for peritoneal dialysis under the trade name Extraneal and after gynecological laparoscopic surgery for the reduction of post-surgical adhesions (fibrous bands that form between tissues and organs) under the trade name Adept. Icodextrin is a starch-derived, water-soluble glucose polymer linked by alpha (1-4) and less than 10% alpha (1-6) glucosidic bonds. Icodextrin. Icodextrin acts in the peritoneal cavity by exerting osmotic pressure across small intercellular pores resulting in transcapillary ultrafiltration throughout the dwell. Like other peritoneal dialysis solutions, Extraneal also contains electrolytes to help normalize electrolyte balance and lactate to help normalize acid-base status. Absorption of icodextrin from the peritoneal cavity follows zero-order kinetics consistent with convective transport via peritoneal lymphatic pathways. Icodextrin is metabolized by alpha-amylase into oligosaccharides with a lower degree of polymerization, including maltose, maltotriose, maltotetraose, and higher molecular weight species

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
EXTRANEAL

Approved Use

EXTRANEAL (icodextrin) is indicated for a single daily exchange for the long (8- to 16- hour) dwell during continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) for the management of end-stage renal disease. EXTRANEAL is also indicated to improve (compared to 4.25% dextrose) long-dwell ultrafiltration and clearance of creatinine and urea nitrogen in patients with high average or greater transport characteristics, as defined using the peritoneal equilibration test (PET) [see Clinical Pharmacology (12), Clinical Studies (14)

Launch Date

1.04034238E12
Name Type Language
ICODEXTRIN
HSDB   INN   JAN   MART.   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
ICODEXTRIN [WHO-DD]
Common Name English
DEXTRIN [WHO-DD]
Common Name English
ICODEXTRIN [VANDF]
Common Name English
ICODEXTRIN [JAN]
Common Name English
A COMPLEX POLYGLUCOPYRANOSE PRODUCED BY THE ENZYMATIC HYDROLYSIS OF CORN. IT IS PRIMARILY COMPOSED OF .ALPHA.-1,4-GLUCOPYRANOSE LINKAGE WITH LESS THAT 10 PERCENT .ALPHA.-1,6 LINKAGE
Common Name English
ICODEXTRIN [MART.]
Common Name English
DEXTRIN (20000 MW)
Common Name English
ICODEXTRIN [USAN]
Common Name English
EXTRANEAL
Brand Name English
DEXTRIN [INCI]
Common Name English
DEXTRIN [VANDF]
Common Name English
ICODEXTRIN [HSDB]
Common Name English
DEXTRIN [II]
Common Name English
ICODEXTRIN [INN]
Common Name English
ICODEXTRIN [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C82130
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
FDA ORPHAN DRUG 105697
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
Code System Code Type Description
MESH
C105834
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
EVMPD
SUB12443MIG
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
FDA UNII
2NX48Z0A9G
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
EPA CompTox
337376-15-5
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
INN
7048
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
CAS
337376-15-5
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
DRUG CENTRAL
4105
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
WIKIPEDIA
ICODEXTRIN
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201472
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
DRUG BANK
DB00702
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
NCI_THESAURUS
C75647
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
HSDB
7840
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY
RXCUI
140480
Created by admin on Sat Jun 26 18:58:35 UTC 2021 , Edited by admin on Sat Jun 26 18:58:35 UTC 2021
PRIMARY RxNorm
Display Structure of ICODEXTRIN