Details
Stereochemistry | UNKNOWN |
Molecular Formula | C10H16N2O2S |
Molecular Weight | 228.311 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)C1(CC)C(=O)NC(=S)NC1=O
InChI
InChIKey=IDELNEDBPWKHGK-UHFFFAOYSA-N
InChI=1S/C10H16N2O2S/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)
Thiobutabarbital is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, it is used in veterinary medicine for induction in surgical anaesthesia. Thiobutabarbital was formerly used as anesthetic Inactin. ‘Inactin’ (sodium thiobutabarbital) produces smooth induction of anaesthesia after intravenous administration and has a prolonged duration of action. It has variable analgesic activity.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0008645 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7819247 |
1.0 mM [IC50] | ||
Target ID: GO:0008645 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7819247 |
1.0 mM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Inactin Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Effects of BW245C, a prostaglandin dp receptor agonist, on systemic and regional haemodynamics in the anaesthetized rat. | 2005 Nov |
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The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes. | 2005 Nov |
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Total synthesis of the proposed structure of brevenal. | 2006 Aug 2 |
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The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro. | 2006 Jul |
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Vasodilator effect of nicorandil on retinal blood vessels in rats. | 2007 Jul |
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Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats. | 2007 Jun |
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Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells. | 2008 |
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Glucose-induced time-dependent potentiation of insulin release, but not islet blood perfusion, in anesthetized rats. | 2008 |
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Low-dose candesartan improves renal blood flow and kidney oxygen tension in rats with endotoxin-induced acute kidney dysfunction. | 2008 Aug |
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Reversal of high pancreatic islet and white adipose tissue blood flow in type 2 diabetic GK rats by administration of the beta3-adrenoceptor inhibitor SR-59230A. | 2009 Aug |
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Resistin increases islet blood flow and decreases subcutaneous adipose tissue blood flow in anaesthetized rats. | 2009 Feb |
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Total synthesis of brevenal. | 2009 Jun 18 |
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High-NaCl intake impairs dynamic autoregulation of renal blood flow in ANG II-infused rats. | 2010 Nov |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19881310
Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)).
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7819247
Thiobutabarbital inhibits hexose transport in cultured 3T3-C2 cells with IC50 value of 1.0 mM.
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C67084
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C87670
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Thiobutabarbital
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C004316
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SUBSTANCE RECORD