U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry UNKNOWN
Molecular Formula C10H16N2O2S
Molecular Weight 228.311
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIOBUTABARBITAL

SMILES

CCC(C)C1(CC)C(=O)NC(=S)NC1=O

InChI

InChIKey=IDELNEDBPWKHGK-UHFFFAOYSA-N
InChI=1S/C10H16N2O2S/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)

HIDE SMILES / InChI

Description

Thiobutabarbital is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, it is used in veterinary medicine for induction in surgical anaesthesia. Thiobutabarbital was formerly used as anesthetic Inactin. ‘Inactin’ (sodium thiobutabarbital) produces smooth induction of anaesthesia after intravenous administration and has a prolonged duration of action. It has variable analgesic activity.

CNS Activity

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 1.0 mM [IC50]
Inhibitor
8504
 1.0 mM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
Inactin

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
2001 Aug
Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats.
2002 Feb
Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats.
2002 Jan
Chemoprophylaxis of transfusion-transmitted agents in labile blood components.
2002 Jul-Aug
Propofol anesthesia compared to awake reduces infarct size in rats.
2002 May
Oxytocin-induced renin secretion by denervated kidney in anaesthetized rat.
2002 Nov 15
Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays.
2004 Aug
Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia.
2004 Oct
Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline.
2004 Oct
AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension.
2005 Feb
Differential effects of isoflurane and ketamine/inactin anesthesia on cAMP and cardiac function in FVB/N mice during basal state and beta-adrenergic stimulation.
2005 Mar
Effects of BW245C, a prostaglandin dp receptor agonist, on systemic and regional haemodynamics in the anaesthetized rat.
2005 Nov
The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes.
2005 Nov
Antenatal Corticosteroids and Postnatal Fluid Restriction Produce Differential Effects on AQP3 Expression, Water Handling, and Barrier Function in Perinatal Rat Epidermis.
2010
Gastric emptying of enterally administered liquid meal in conscious rats and during sustained anaesthesia.
2010 Feb
Patents

Patents

US6562363
4
US6638528
14
WO2009151744A1
2

Sample Use Guides

In Vivo Use Guide
Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)).
Route of Administration: Intraperitoneal
In Vitro Use Guide
Thiobutabarbital inhibits hexose transport in cultured 3T3-C2 cells with IC50 value of 1.0 mM.
Name Type Language
THIOBUTABARBITAL
MI   VANDF   WHO-DD  
Common Name English
NSC-27685
Preferred Name English
5-ETHYL-5-(1-METHYLPROPYL)-2-THIOBARBITURIC ACID
Systematic Name English
Thiobutabarbital [WHO-DD]
Common Name English
5-SEC-BUTYL-5-ETHYL-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE
Systematic Name English
THIOBUTABARBITAL [MI]
Common Name English
NSC-32372
Code English
5-ETHYLDIHYDRO-5-(1-METHYLPROPYL)-2-THIOXO-4,6(1H,5H)-PYRIMIDINEDIONE
Systematic Name English
5-SEC-BUTYL-5-ETHYL-2-THIOBARBITURIC ACID
Systematic Name English
THIOBUTABARBITAL [VANDF]
Common Name English
THIBUTABARBITAL
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67084
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
Code System Code Type Description
NSC
32372
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
EPA CompTox
DTXSID90871862
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
EVMPD
SUB15533MIG
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
ECHA (EC/EINECS)
218-260-0
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
NCI_THESAURUS
C87670
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
WIKIPEDIA
Thiobutabarbital
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
FDA UNII
2N0251U7JH
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
PUBCHEM
3032373
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
RXCUI
38077
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY RxNorm
CAS
2095-57-0
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
MERCK INDEX
m10746
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY Merck Index
SMS_ID
100000077014
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
NSC
27685
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
MESH
C004316
Created by admin on Mon Mar 31 18:31:48 GMT 2025 , Edited by admin on Mon Mar 31 18:31:48 GMT 2025
PRIMARY
SUBSTANCE RECORD
Structure of THIOBUTABARBITAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966