Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H23NO2 |
| Molecular Weight | 345.4342 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CO)(CO)NCC1=CC2=C(C=CC3=CC=CC=C23)C4=CC=CC=C14
InChI
InChIKey=SBRXTSOCZITGQG-UHFFFAOYSA-N
InChI=1S/C23H23NO2/c1-23(14-25,15-26)24-13-17-12-22-18-7-3-2-6-16(18)10-11-21(22)20-9-5-4-8-19(17)20/h2-12,24-26H,13-15H2,1H3
Crisnatol is a derivative of arylmethylaminopropanediol with significant antineoplastic activity in a variety of murine and human tumor models. Crisnatol functions as a DNA intercalator, with the presence of additional basic amine groups in the sidechain enhancing binding to DNA due to electrostatic interactions. Crisnatol did not show antitumor efficacy in patients with ovarian carcinoma. In another clinical study, 2 of 26 patients with glioma showed complete long-lasting responses to the drug. The dose-limiting side effect was neurotoxicity.
Approval Year
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Official Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C582
Created by
admin on Wed Apr 02 09:06:09 GMT 2025 , Edited by admin on Wed Apr 02 09:06:09 GMT 2025
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57062
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96389-68-3
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2J71UR51UE
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C81191
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100000083718
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CHEMBL61495
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C056722
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SUB06820MIG
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DTXSID10242217
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Crisnatol
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admin on Wed Apr 02 09:06:09 GMT 2025 , Edited by admin on Wed Apr 02 09:06:09 GMT 2025
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6225
Created by
admin on Wed Apr 02 09:06:09 GMT 2025 , Edited by admin on Wed Apr 02 09:06:09 GMT 2025
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
