SCH-486757

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H23Cl2N3O
Molecular Weight	440.365
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@]1(C[C@@H]2CC[C@H](C1)N2C(C3=CC=CC=C3Cl)C4=CC=CC=C4Cl)C5=NC=CC=N5

InChI

InChIKey=MQWMHMZNBGQNMT-XHNJZIHCSA-N

InChI=1S/C24H23Cl2N3O/c25-20-8-3-1-6-18(20)22(19-7-2-4-9-21(19)26)29-16-10-11-17(29)15-24(30,14-16)23-27-12-5-13-28-23/h1-9,12-13,16-17,22,30H,10-11,14-15H2/t16-,17+,24-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19937046 | https://adisinsight.springer.com/drugs/800038184

SCH486757 was invented as a selective nociceptin/orphanin FQ peptide (NOP) receptor agonist. SCH486757 participated in phase II clinical trial for the treatment of cough, however, this study was discontinued.

Approval Year

PubMed

Title	Date	PubMed
Regulating cough through modulation of sensory nerve function in the airways.	2013-10	23524012
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.	2010-03-25	20006596

Sample Use Guides

In Vivo Use Guide

Subjects were randomised to receive either SCH486757 100 mg, codeine 30 mg, or matched placebo twice daily for 5 days

Route of Administration: Oral

Name

Type

Language

SCH-486757

Common Name

English

SCH 486757

Preferred Name

English

SCH486757

Code

English

8-AZABICYCLO(3.2.1)OCTAN-3-OL, 8-(BIS(2-CHLOROPHENYL)METHYL)-3-(2-PYRIMIDINYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

11597355