FLUTOPRAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H16ClFN2O
Molecular Weight	342.795
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=C(C=CC=C1)C2=NCC(=O)N(CC3CC3)C4=C2C=C(Cl)C=C4

InChI

InChIKey=OFVXPDXXVSGEPX-UHFFFAOYSA-N

InChI=1S/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2

HIDE SMILES / InChI

Description
Sources: https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=010277&item_branch=002
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/6148044

Flutoprazepam is a benzodiazepine derivative that reduce anxiety, stress, depression, fatigability and sleep disorders in patients with neurosis and psychosomatic disorders by binding to GABA-A receptor and modulating its activity.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=010277&item_branch=002	Agonist 2678		13.0 nM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Anxiety 267 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6148044	Primary	Approved 8429	RESTAS Approved Use It is usually used for the improvement of anxiety, stress and depression; fatigability; and sleep disorder associated with neurosis and psychosomatic disorder (hypertension, gastric and duodenal ulcer, chronic gastritis, irritable bowel syndrome), and psychosomatic symptoms.
Sleep disorder 20 Sources: https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=010277&item_branch=002	Primary	Approved 8429	RESTAS Approved Use It is usually used for the improvement of anxiety, stress and depression; fatigability; and sleep disorder associated with neurosis and psychosomatic disorder (hypertension, gastric and duodenal ulcer, chronic gastritis, irritable bowel syndrome), and psychosomatic symptoms.
Stress and depression 1 Sources: https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=010277&item_branch=002	Primary	Approved 8429	RESTAS Approved Use It is usually used for the improvement of anxiety, stress and depression; fatigability; and sleep disorder associated with neurosis and psychosomatic disorder (hypertension, gastric and duodenal ulcer, chronic gastritis, irritable bowel syndrome), and psychosomatic symptoms.

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

For adults, take 1 to 2 tablets (2 to 4 mg of the active ingredient) in 1 to 2 divided doses daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

FLUTOPRAZEPAM

Official Name

English

RESTAS

Brand Name

English

FLUTOPRAZEPAM [MART.]

Common Name

English

7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(O-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE

Common Name

English

FLUTOPRAZEPAM [JAN]

Common Name

English

FLUTOPRAZEPAM [MI]

Common Name

English

flutoprazepam [INN]

Common Name

English

Flutoprazepam [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012