SPERMINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H26N4
Molecular Weight	202.3402
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NCCCNCCCCNCCCN

InChI

InChIKey=PFNFFQXMRSDOHW-UHFFFAOYSA-N

InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase IV	Inhibitor	10.0 nM [Ki]
Carbonic anhydrase VII	Inhibitor	710.0 nM [Ki]
Carbonic anhydrase VB	Inhibitor	830.0 nM [Ki]
Carbonic anhydrase VA	Inhibitor	840.0 nM [Ki]
Glutamate NMDA receptor	Activator	5.2 µM [EC50]

PubMed

Show entries

Title	Date	PubMed
Polyamines of the hyperthermophilic archaebacteria belonging to the genera Thermococcus and Methanothermus and two new genera Caldivirga and Palaeococcus.	2001	11297011
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.	2001	11291831
Structure-activity analysis of the potentiation by aminothiols of the chromosome-damaging effect of bleomycin in G0 human lymphocytes.	2001	11246218
Transgenic manipulation of the metabolism of polyamines in poplar cells.	2001 Apr	11299393
Spermine mediates inward rectification in potassium channels of turtle retinal Müller cells.	2001 Apr	11287460

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Patents

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Name

Type

Language

SPERMINE

Systematic Name

English

GEROTINE

Official Name

English

NSC-268508

Code

English

1,4-BUTANEDIAMINE, N,N'-BIS(3-AMINOPROPYL)-

Systematic Name

English

GEROTINE [INCI]

Common Name

English

Showing 1 to 5 of 12 entries

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Classification Tree

Code System

Code

Nitrogen Compound

NCI_THESAURUS

C759

Showing 1 to 1 of 1 entries

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Code System

Code

Type

Description

CAS

71-44-3

PRIMARY

WIKIPEDIA

SPERMINE

PRIMARY

CHEBI

45725

PRIMARY

EPA CompTox

DTXSID9058781

PRIMARY

DAILYMED

2FZ7Y3VOQX

PRIMARY

Showing 1 to 5 of 15 entries

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ACTIVE MOIETY


					2FZ7Y3VOQX

SPERMINE