MIFENTIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H16N4
Molecular Weight	228.2929
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N\C=N\C1=CC=C(C=C1)C2=CN=CN2

InChI

InChIKey=GOZUADYOHPCXLE-UHFFFAOYSA-N

InChI=1S/C13H16N4/c1-10(2)15-9-16-12-5-3-11(4-6-12)13-7-14-8-17-13/h3-10H,1-2H3,(H,14,17)(H,15,16)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1981748 | https://adisinsight.springer.com/drugs/800000605

Mifentidine, a histamine H2 receptor antagonist, was studied to treat the duodenal ulcer. This drug was in phase II clinical trials when apparently further researches had been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H2 receptor 46 Target ID: P25021 Gene ID: 3274.0 Gene Symbol: HRH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8931893	Antagonist 2778

PubMed

Title	Date	PubMed
Mifentidine: evaluation of antiandrogen effects and kidney function studies.	1985	2859037
The effect of the new H2-receptor antagonist mifentidine on gastric secretion, gastric emptying and experimental gastric and duodenal ulcers in the rat: comparison with cimetidine and ranitidine.	1986	2866139
In vivo-in vitro correlations with a commercial dissolution simulator. Studies on the H2 receptor antagonist mifentidine.	1996 Oct	8931893
In vitro studies on the metabolic fate of mifentidine, a novel histamine H2-receptor antagonist.	1997 Apr-Jun	9248785

Sample Use Guides

In Vivo Use Guide

mifentidine 20 mg at night

Route of Administration: Oral

Name

Type

Language

MIFENTIDINE

Official Name

English

MIFENTIDINE [MART.]

Common Name

English

mifentidine [INN]

Common Name

English

N-(P-IMIDAZOL-4-YLPHENYL)-N'-ISOPROPYLFORMAMIDINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578