Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H17NO |
| Molecular Weight | 203.2802 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(C(=O)\C=C\C)C1=C(C)C=CC=C1
InChI
InChIKey=DNTGGZPQPQTDQF-XBXARRHUSA-N
InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use. The drug was approved by FDA for the treatment of scabies and pruritic skin. Crotamiton is a mixture of the cis and trans isomers of N-ethyl-N-(o-methylphenyl)-2butenamide. Although the activity of crotamiton was shown both in vitro and in vivo, the mechanism of its action is still unknown.
Originator
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | EURAX Approved UseFor eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin. Launch Date1949 |
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| Palliative | EURAX Approved UseFor eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin. Launch Date1949 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses. | 1949 Jul |
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| [Crotamiton and crotamiton hydrocortisone compounds in the treatment of pruritus]. | 1965 Aug 20 |
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| Crotamiton cream and lotion in the treatment of infants and young children with scabies. | 1979 |
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| A single application of crotamiton lotion in the treatment of patients with pediculosis capitis. | 1982 Dec |
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| Crotamiton lotion in pruritus. | 1984 Dec |
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| Contact dermatitis due to crotamiton. | 1986 Oct |
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| The sensitizing capacity of crotamiton. | 1988 May |
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| Treatment of scabies with crotamiton. | 1988 May |
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| Contact dermatitis from crotamiton. | 1992 Jul |
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| Chromatography of crotamiton and its application to the determination of active ingredients in ointments. | 1997 Jun |
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| Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream. | 2013 |
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| Topical ivermectin versus crotamiton cream 10% for the treatment of scabies. | 2014 Jul |
Patents
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2EEH27851Y
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124236-29-9
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688020
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admin on Fri Dec 15 15:28:47 GMT 2023 , Edited by admin on Fri Dec 15 15:28:47 GMT 2023
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SUBSTANCE RECORD
