Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H12N4O6S |
Molecular Weight | 316.29 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(SC(=O)N2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI
InChIKey=TZYVRXZQAWPIAB-FCLHUMLKSA-N
InChI=1S/C10H12N4O6S/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8/h2-4,8,15-17H,1H2,(H3,11,12,13,18)/t2-,3-,4-,8-/m1/s1
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. | 1989 Sep |
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Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents. | 1990 Aug |
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Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine. | 1990 Feb |
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Roles of interferon and natural killer cells in the antiviral activity of 7-thia-8-oxoguanosine against Semliki Forest virus infections in mice. | 1990 Feb |
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Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents. | 1990 Jan |
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Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system. | 1991 Oct |
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Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines. | 1993 Oct 29 |
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Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections. | 1994 Oct |
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Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats. | 1995 Mar |
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Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. | 2005 Sep |
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Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease. | 2006 Aug |
Patents
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C308
Created by
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7843
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135409474
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C90812
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122970-40-5
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2DNT962H92
Created by
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DTXSID20924330
Created by
admin on Fri Dec 15 16:55:52 GMT 2023 , Edited by admin on Fri Dec 15 16:55:52 GMT 2023
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ACTIVE MOIETY
PRODRUG (METABOLITE ACTIVE)
SALT/SOLVATE (PARENT)