Pipebuzone (LD 4644) is an anti-inflammatory, antipyretic and analgesic agent. Pipebuzone was used for the treatment of various rheumatic diseases. It was particularly well tolerated, clinically and pathologically, and had a reliable anti inflammatory action. This action was especially dramatic in the acute inflammatory rheumatisms and particularly in the microcrystalline arthropathies, gout and chondrocalcinosis. It was in the treatment of the latter that the drug was most consistently successful and quick acting. With chronic rheumatism its action was again noteworthy in the case of rheumatic pelvic spondylitis. Pipebuzone was also used in odonto-stomatology and maxillo-facial surgery, for the protection of the pulp in a conjoined prosthesis.