SOTORASIB

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H30F2N6O3
Molecular Weight	560.5944
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0
Stereo Comments	AXIAL, R

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=NC=CC(C)=C1N2C(=O)N=C(N3CCN(C[C@@H]3C)C(=O)C=C)C4=C2N=C(C(F)=C4)C5=C(F)C=CC=C5O

InChI

InChIKey=NXQKSXLFSAEQCZ-SFHVURJKSA-N

InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

HIDE SMILES / InChI

Approval Year

Name

Type

Language

SOTORASIB

Official Name

English

SOTORASIB [JAN]

Common Name

English

SOTORASIB [ORANGE BOOK]

Common Name

English

sotorasib [INN]

Common Name

English

KRAS MUTANT-TARGETING AMG 510

Common Name

English

Sotorasib [WHO-DD]

Common Name

English

PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4-METHYL-2-(1-METHYLETHYL)-3-PYRIDINYL)-4-((2S)-2-METHYL-4-(1-OXO-2-PROPEN-1-YL)-1-PIPERAZINYL)-

Systematic Name

English

PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4-METHYL-2-(1-METHYLETHYL)-3-PYRIDINYL)-4-((2S)-2-METHYL-4-(1-OXO-2-PROPEN-1-YL)-1-PIPERAZINYL)-, (1R)-

Systematic Name

English

AMG-510

Code

English

LUMAKRAS

Brand Name

English

AMG510

Code

English

(1RA)-6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-4-((2S)-2-METHYL-4-(1-OXOPROP-2-EN-1-YL)PIPERAZIN-1-YL)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Systematic Name

English

(1M)-6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)-4-((2S)-2-METHYL-4-(PROP-2-ENOYL)PIPERAZIN-1-YL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Systematic Name

English

SOTORASIB [USAN]

Common Name

English

6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-(1M)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)-4-((2S)-2-METHYL-4-(PROP-2-ENOYL)PIPERAZIN-1-YL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Systematic Name

English

KRAS G12C INHIBITOR 9

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

654918