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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H30F2N6O3
Molecular Weight 560.5955
Optical Activity UNSPECIFIED
Additional Stereochemistry Yes
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0
Stereo Comments AXIAL, R

SHOW SMILES / InChI
Structure of SOTORASIB

SMILES

C=CC(=O)N1CCN([C@@]([H])(C)C1)c2c3cc(c(-c4c(cccc4O)F)nc3n(-c5c(C)ccnc5C(C)C)c(=O)n2)F

InChI

InChIKey=NXQKSXLFSAEQCZ-SFHVURJKSA-N
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

HIDE SMILES / InChI

Approval Year

Name Type Language
SOTORASIB
USAN   INN  
Official Name English
SOTORASIB [INN]
Common Name English
KRAS MUTANT-TARGETING AMG 510
Common Name English
SOTORASIB [WHO-DD]
Common Name English
PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4-METHYL-2-(1-METHYLETHYL)-3-PYRIDINYL)-4-((2S)-2-METHYL-4-(1-OXO-2-PROPEN-1-YL)-1-PIPERAZINYL)-
Systematic Name English
PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4- METHYL-2-(1-METHYLETHYL)-3-PYRIDINYL)-4-((2S)-2-METHYL-4-(1-OXO-2-PROPEN-1-YL)-1- PIPERAZINYL)-, (1R)-
Systematic Name English
AMG-510
Code English
LUMAKRAS
Brand Name English
AMG510
Code English
(1RA)-6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-4-((2S)-2-METHYL-4-(1-OXOPROP-2-EN-1- YL)PIPERAZIN-1-YL)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)PYRIDO(2,3-D)PYRIMIDIN- 2(1H)-ONE
Systematic Name English
(1M)-6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)-4-((2S)-2-METHYL-4-(PROP-2-ENOYL)PIPERAZIN-1-YL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE
Systematic Name English
SOTORASIB [USAN]
Common Name English
6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-(1M)-1-(4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL)-4-((2S)-2-METHYL-4-(PROP-2-ENOYL)PIPERAZIN-1-YL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE
Systematic Name English
KRAS G12C INHIBITOR 9
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 654918
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
FDA ORPHAN DRUG 653818
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
Code System Code Type Description
FDA UNII
2B2VM6UC8G
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY
PUBCHEM
137278711
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY
CAS
2252403-56-6
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
NON-SPECIFIC STEREOCHEMISTRY
CAS
2296729-00-3
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY
DRUG BANK
DB15569
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY
INN
11370
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY
NCI_THESAURUS
C154287
Created by admin on Fri Jun 25 21:24:15 UTC 2021 , Edited by admin on Fri Jun 25 21:24:15 UTC 2021
PRIMARY