Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H5Cl5 |
| Molecular Weight | 326.433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1Cl)C2=C(Cl)C=C(Cl)C(Cl)=C2
InChI
InChIKey=IUTPYMGCWINGEY-UHFFFAOYSA-N
InChI=1S/C12H5Cl5/c13-8-2-1-6(3-10(8)15)7-4-11(16)12(17)5-9(7)14/h1-5H
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners. | 1999 Aug 15 |
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| Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls. | 2000 Sep 15 |
|
| Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. | 2002 Aug |
|
| Effect of low dose mono-ortho 2,3',4,4',5 pentachlorobiphenyl on thyroid hormone status and EROD activity in rat offspring: consequences for risk assessment. | 2003 Apr 15 |
|
| Effects of single non-ortho, mono-ortho, and di-ortho chlorinated biphenyls on cell functions and proliferation of the human prostatic carcinoma cell line, LNCaP. | 2003 Mar-Apr |
|
| Detectable dioxins in human saliva and their effects on gingival epithelial cells. | 2003 Oct |
|
| Proliferative effects of estradiol, progesterone, and two CB congeners and their metabolites on gray seal (Halichoerus grypus) uterine myocytes in vitro. | 2003 Sep |
|
| Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. | 2005 Jul |
|
| Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. | 2005 May-Jun |
|
| Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. | 2006 Dec |
|
| Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). | 2006 Nov |
|
| Application of an ELISA for PCB 118 to the screening of dioxin-like PCBs in retail fish. | 2006 Oct |
|
| Pathways and products of the degradation of PCBs by the sodium dispersion method. | 2007 Jun |
|
| Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. | 2007 Nov |
|
| Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 Apr |
|
| Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. | 2008 Dec |
|
| Chemical and bioassay monitoring of PCB-contaminated soil remediation using solvent extraction technology. | 2008 Feb |
|
| Serum concentrations of indicator PCB congeners in the Czech adult population. | 2008 Jul |
|
| Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. | 2008 Jul |
|
| Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan. | 2008 Jul |
|
| Biosensor immunoassay for the screening of dioxin-like polychlorinated biphenyls in retail fish. | 2008 Jun 9 |
|
| PCB 118 and Aryl Hydrocarbon Receptor Immunoassays for Screening Dioxins in Retail Fish. | 2008 May 14 |
|
| Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. | 2009 Apr |
|
| Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. | 2009 Dec 10 |
|
| Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. | 2010 Dec |
|
| Highly purified hexachlorobenzene induces cytochrome P4501A in primary cultures of chicken embryo hepatocytes. | 2010 Nov 1 |
|
| Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. | 2010 Sep |
|
| In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. | 2011 Jan |
|
| In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans. | 2011 May |
|
| Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs. | 2011 Oct 10 |
|
| Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling. | 2012 Dec 16 |
|
| Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. | 2013 Jul |
|
| Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. | 2015 Apr 1 |
|
| Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. | 2015 Apr 20 |
|
| Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample. | 2015 Jul |
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| Code System | Code | Type | Description | ||
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31508-00-6
Created by
admin on Fri Dec 15 19:05:12 GMT 2023 , Edited by admin on Fri Dec 15 19:05:12 GMT 2023
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35823
Created by
admin on Fri Dec 15 19:05:12 GMT 2023 , Edited by admin on Fri Dec 15 19:05:12 GMT 2023
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DTXSID4032116
Created by
admin on Fri Dec 15 19:05:12 GMT 2023 , Edited by admin on Fri Dec 15 19:05:12 GMT 2023
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2B2AQE8U50
Created by
admin on Fri Dec 15 19:05:12 GMT 2023 , Edited by admin on Fri Dec 15 19:05:12 GMT 2023
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PRIMARY |
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