Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C18H22N2O2 |
| Molecular Weight | 298.3795 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NCC(O)COC1=CC=CC2=C1C3=CC=CC=C3N2
InChI
InChIKey=BQXQGZPYHWWCEB-UHFFFAOYSA-N
InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
Carazolol is a beta1/beta2 adrenoreceptor blocking agent. Activity and safety of the drug were evaluated in clinical trials that were conducted in healthy subjects and in patients suffering from either chronic bronchitis or asthma. The drug, however, was not developed for human use. Instead, carazolol is used in to reduce stress in animals during transportation. In veterinary medicine, carazolol is given by intramuscular injection to pigs is indicated in stress-inducing situations. In cattle, carazolol is intended to be used for the prevention of shipment stress caused by transportation and formation of new herds.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation. | 2006 Nov |
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| Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells. | 2006 Nov |
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| Effect of carazolol on the oestrous behaviour and concentrations of luteinising hormone and steroids in lactating cows during the periovulatory period. | 2007 Jun 9 |
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| Determination of residues of azaperone in the kidneys by liquid chromatography with fluorescence detection. | 2007 Mar 14 |
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| Biochemistry. Signaling across the cell membrane. | 2007 Nov 23 |
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| High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. | 2007 Nov 23 |
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| GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. | 2007 Nov 23 |
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| Crystallizing thinking about the beta2-adrenergic receptor. | 2008 May |
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| On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. | 2008 May 22 |
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| Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance. | 2008 Nov 7 |
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| Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. | 2010 Jan 7 |
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| Lambing rates and litter size following carazolol administration prior to insemination in Kivircik ewes. | 2010 Mar |
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| Cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials. | 2010 Mar 15 |
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| Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 Mar 16 |
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| A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors. | 2010 Nov 30 |
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QC07AA90
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C29576
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260-945-1
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20192
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m3050
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71739
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DTXSID00866648
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CHEMBL324665
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Carazolol
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57775-29-8
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C77941
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SUB06086MIG
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487
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C014382
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ACTIVE MOIETY
