TALAMPICILLIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	EPIMERIC
Molecular Formula	C24H23N3O6S
Molecular Weight	481.521
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TALAMPICILLIN

Structure Search

SMILES

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CC=CC=C3)C(=O)OC4OC(=O)C5=C4C=CC=C5

InChI

InChIKey=SOROUYSPFADXSN-SUWVAFIASA-N

InChI=1S/C24H23N3O6S/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28)/t15-,16-,17+,20-,23?/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328

The phthalidyl thiazolidine carboxylic ester of ampicillin, talampicillin (Talpen, Beecham), has been introduced recently to improve absorption and to reduce these side effects. After oral administration talampicillin is rapidly absorbed and hydrolysed by tissue esterases in the intestinal wall to release into the circulation ampicillin and the ester moiety, mainly 2-hydroxymethyl-benzoic acid. No unchanged talampicillin is detectable in the peripheral blood. It is not approved by the FDA for use in the United States

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial penicillin-binding protein 233 Target ID: CHEMBL2354204 Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328	Inhibitor 8297

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Urinary tract infections 205 Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328	Curative		Approved 8429	Talpen Approved Use Unknown

PubMed

PubMed

Title	Date	PubMed
Kinetics of talampicillin decomposition in solutions.	2002 Jan-Feb	12026108

Patents

Patents

Sample Use Guides

In Vivo Use Guide

for seven days at a dosage of 390 mg three times daily or 750 mg twice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

TALAMPICILLIN

Official Name

English

TALAMPICILLIN HYDROCHLORIDE [JAN]

Common Name

English

TALAMPICILLIN [MI]

Common Name

English

BRL-8988

Code

English

BRL 8988

Code

English

(2S,5R,6R)-6-((R)-2-AMINO-2-PHENYLACETAMIDO)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID ESTER WITH 3-HYDROXYPHTHALIDE

Common Name

English

Talampicillin [WHO-DD]

Common Name

English

talampicillin [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QJ01CA15

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

NCI_THESAURUS

C1500

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

WHO-ATC

J01CA15

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

Code System Code Type Description

MERCK INDEX

m10435

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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Merck Index

FDA UNII

29OJI73DPC

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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DRUG BANK

DB13814

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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EPA CompTox

DTXSID1048540

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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RXCUI

10322

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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RxNorm

ECHA (EC/EINECS)

256-332-3

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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MESH

D013626

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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NCI_THESAURUS

C152492

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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CHEBI

9391

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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WIKIPEDIA

TALAMPICILLIN

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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CAS

47747-56-8

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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PUBCHEM

71447

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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DRUG CENTRAL

2554

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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SMS_ID

100000083015

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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EVMPD

SUB10800MIG

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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ChEMBL

CHEMBL1619785

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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INN

3607

Created by admin on Fri Dec 15 16:24:38 GMT 2023 , Edited by admin on Fri Dec 15 16:24:38 GMT 2023

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ACTIVE MOIETY


					29OJI73DPC

SALT/SOLVATE (PARENT)


					JB791E7242

TALAMPICILLIN NAPSILATE

SALT/SOLVATE (PARENT)


					4C5O3X072I

TALAMPICILLIN HYDROCHLORIDE