Details
Stereochemistry | EPIMERIC |
Molecular Formula | C24H23N3O6S |
Molecular Weight | 481.521 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CC=CC=C3)C(=O)OC4OC(=O)C5=C4C=CC=C5
InChI
InChIKey=SOROUYSPFADXSN-SUWVAFIASA-N
InChI=1S/C24H23N3O6S/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28)/t15-,16-,17+,20-,23?/m1/s1
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/776328
Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328
The phthalidyl thiazolidine carboxylic ester of ampicillin, talampicillin (Talpen, Beecham), has been introduced recently to improve absorption and to reduce these side effects. After oral administration talampicillin is rapidly absorbed and hydrolysed by tissue esterases in the intestinal wall to release into the circulation ampicillin and the ester moiety, mainly 2-hydroxymethyl-benzoic acid. No unchanged talampicillin is detectable in the peripheral blood. It is not approved by the FDA for use in the United States
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2354204 Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Talpen Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Talampicillin in the treatment and prophylaxis of urinary tract infection in children. | 1982 |
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Evaluation of oral antimicrobial agent levels in tooth extraction sites. | 2001 Jun |
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Kinetics of talampicillin decomposition in solutions. | 2002 Jan-Feb |
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Effects of treatment with antimicrobial agents on the human colonic microflora. | 2008 Dec |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/776328
for seven days at a dosage of 390 mg three times daily or 750 mg twice daily
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QJ01CA15
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NCI_THESAURUS |
C1500
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WHO-ATC |
J01CA15
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m10435
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29OJI73DPC
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DB13814
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DTXSID1048540
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10322
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256-332-3
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D013626
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C152492
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9391
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TALAMPICILLIN
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47747-56-8
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71447
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2554
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100000083015
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SUB10800MIG
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CHEMBL1619785
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3607
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)