| Stereochemistry | RACEMIC |
| Molecular Formula | C10H12N2O3 |
| Molecular Weight | 208.2139 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(CC(=O)C1=CC=CC=C1N)C(O)=O
InChI
InChIKey=YGPSJZOEDVAXAB-UHFFFAOYSA-N
InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)
DL-Kynurenine is a racemic mixture of D-kynurenine and L-kynurenine. Kynurenine is the precursor of kynurenic acid, an endogenous antagonist of the glycine site of the NMDA (N-methyl-D-aspartate) receptor. Kynurenine has been identified as an endogenous ligand of the aryl hydrocarbon receptor (AhR), a receptor known to be activated by various environmental toxicants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Rats were treated with DL-Kynurenine at 150, 300 and 450 mg/kg
Route of Administration:
Intraperitoneal
HepG2 cells were cultured in a humidified atmosphere containing 5% CO2 for 24 hours under basal conditions and for another 24 hours under the evaluated conditions. Cells were cultured in six-well plates at 5 x 10^5 /well, except during the LDH release assay, when cells were cultured in 96-well plates at 10^4 /well. Cells were maintained untreated or treated with 100 mmol/L CoCl2, 50 mmol/L kynurenine, or 3 mmol/L CH223191 or various combinations. Cytotoxicity was assessed by LDH-release assay
SUBSTANCE RECORD
