Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2HCl3 |
| Molecular Weight | 131.388 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC=C(Cl)Cl
InChI
InChIKey=XSTXAVWGXDQKEL-UHFFFAOYSA-N
InChI=1S/C2HCl3/c3-1-2(4)5/h1H
Trichloroethylene (or TCE), a synthetic chemical that does not occur naturally in the environment. TCE is used to make chemicals. Additionally, it is used for spot removal in dry cleaning operations. TCE is the most common organic contaminant in groundwater. It was revealed that the compound was a human carcinogen that caused liver cancer, kidney cancer, and non-Hodgkin's lymphoma (NHL).
Approval Year
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| yes [Inhibition 2000 uM] |
Drug as victim
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| major | ||||
| minor | ||||
| minor | ||||
| minor |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Electrochemical remediation of trichloroethene-contaminated groundwater using palladized iron oxides. | 2001 |
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| Alteration of drug kinetics in rats following exposure to trichloroethylene. | 2001 |
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| The importance of reliable exposure estimates in deciding whether trichloroethylene can cause kidney cancer. | 2001 |
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| Substrate interactions during aerobic biodegradation of methane, ethene, vinyl chloride and 1,2-dichloroethenes. | 2001 |
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| Dermal benzene and trichloroethylene induce aneuploidy in immature hematopoietic subpopulations in vivo. | 2001 |
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| Ultrasonic degradation of trichloroethylene and chlorobenzene at micromolar concentrations: kinetics and modelling. | 2001 Apr |
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| Effects of alcohols, anionic and nonionic surfactants on the reduction of PCE and TCE by zero-valent iron. | 2001 Apr |
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| Renal cell cancer correlated with occupational exposure to trichloroethylene. | 2001 Apr |
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| Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification. | 2001 Apr |
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| Evaluation of shale and organoclays as sorbent additives for low-permeability soil containment barriers. | 2001 Apr 1 |
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| Acute exposure to trichloroethylene differentially alters the susceptibility to chemoconvulsants in mice. | 2001 Apr 12 |
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| Measurement of Henry's law constant for methyl tert-butyl ether using solid-phase microextraction. | 2001 Aug |
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| Functional analyses of Bph-Tod hybrid dioxygenase, which exhibits high degradation activity toward trichloroethylene. | 2001 Aug 10 |
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| Remediation of TCE contaminated soils by in situ EK-Fenton process. | 2001 Aug 17 |
|
| Phytotoxicity of chlorinated aliphatics to hybrid poplar (Populus deltoides x nigra DN34). | 2001 Feb |
|
| Factors affecting humic-nickel complex mediated reduction of trichloroethene in homogeneous aqueous solution. | 2001 Feb 15 |
|
| Application of spinel-type cobalt chromite as a novel catalyst for combustion of chlorinated organic pollutants. | 2001 Jan 1 |
|
| Adsorption of trichloroethene at the vapor/water interface. | 2001 Jan 15 |
|
| Stable carbon isotope evidence for intrinsic bioremediation of tetrachloroethene and trichloroethene at area 6, Dover Air Force Base. | 2001 Jan 15 |
|
| Trichloroethylene in urine as biological exposure index. | 2001 Jul |
|
| Aerobic degradation of mixtures of tetrachloroethylene, trichloroethylene, dichloroethylenes, and vinyl chloride by toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1. | 2001 Jul |
|
| In-situ oxidation of trichloroethene by permanganate: effects on porous medium hydraulic properties. | 2001 Jul |
|
| The use of 3M porous polymer extraction discs in assessing protective clothing chemical permeation. | 2001 Jul |
|
| Guar gum reduces trichloroethylene accumulation in the body by reducing TCE absorption and fat tissue mass. | 2001 Jul |
|
| The modelling of trichloroethene photodegradation in Brij 35 surfactant by two-stage reaction. | 2001 Jul |
|
| Applications of ultrasound in NAPL remediation: sonochemical degradation of TCE in aqueous surfactant solutions. | 2001 Jul 15 |
|
| Inverse analyses of transport of chlorinated hydrocarbons subject to sequential transformation reactions. | 2001 Jul-Aug |
|
| Anaesthesia in an unusual location. | 2001 Jun |
|
| Microorganisms relevant to bioremediation. | 2001 Jun |
|
| Development of a biobarrier for the remediation of PCE-contaminated aquifer. | 2001 Jun |
|
| Photodegradation of chlorinated hydrocarbons in the presence and absence of dissolved oxygen in water. | 2001 Jun |
|
| In vitro dehalogenation of tetrachloroethylene (PCE) by cell-free extracts of Clostridium bifermentans DPH-1. | 2001 Jun |
|
| Errors in TCE analysis. | 2001 Mar |
|
| Diversity in kinetics of trichloroethylene-degrading activities exhibited by phenol-degrading bacteria. | 2001 Mar |
|
| Bacterial populations occuring in a trichloroethylene-contaminated aquifer during methane injection. | 2001 Mar |
|
| Use of solvents in industries in Korea: experience in Sinpyeong-Jangrim industrial complex. | 2001 Mar |
|
| Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans. | 2001 Mar |
|
| Variability in carbon isotopic fractionation during biodegradation of chlorinated ethenes: implications for field applications. | 2001 Mar 1 |
|
| "Hepatitic flare", asthenia, peripheral polyneuropathy and diffuse liver steatosis in a hepatitis C virus asymptomatic chronic carrier. | 2001 May |
|
| Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling. | 2001 May |
|
| Determination of chlorinated solvents in exhaled air, urine, and blood of subjects exposed in the workplace using SPME and GC-MS. | 2001 May |
|
| Purification, cloning, and sequencing of an enzyme mediating the reductive dechlorination of tetrachloroethylene (PCE) from Clostridium bifermentans DPH-1. | 2001 May |
|
| Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water. | 2001 May |
|
| Assessment of indigenous reductive dechlorinating potential at a TCE-contaminated site using microcosms, polymerase chain reaction analysis, and site data. | 2001 May 1 |
|
| Risk of pancreatic cancer in workers exposed to chlorinated hydrocarbon solvents and related compounds: a meta-analysis. | 2001 May 1 |
|
| Radiolytic and thermal dechlorination of organic chlorides adsorbed on molecular sieve 13X. | 2001 May 15 |
|
| Biologically-enhanced removal of PCE from NAPL source zones. | 2001 May 15 |
|
| Effects of pH on dechlorination of trichloroethylene by zero-valent iron. | 2001 May 30 |
|
| Travel-time based model of bioremediation using circulation wells. | 2001 May-Jun |
|
| Reductive dehalogenation of chlorinated ethenes with elemental iron: the role of microorganisms. | 2001 Sep |
Patents
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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CFR |
21 CFR 173.290
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C45386
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TRICHLOROETHYLENE
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ACTIVE MOIETY
METABOLITE (PARENT)
