LANIFIBRANOR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H15ClN2O4S2
Molecular Weight	434.916
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCCC1=CC2=C(C=CC(Cl)=C2)N1S(=O)(=O)C3=CC4=C(C=C3)N=CS4

InChI

InChIKey=OQDQIFQRNZIEEJ-UHFFFAOYSA-N

InChI=1S/C19H15ClN2O4S2/c20-13-4-7-17-12(8-13)9-14(2-1-3-19(23)24)22(17)28(25,26)15-5-6-16-18(10-15)27-11-21-16/h4-11H,1-3H2,(H,23,24)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29446942 | http://inventivapharma.com/pipeline/lanifibranor | https://clinicaltrials.gov/ct2/show/NCT03008070 | https://clinicaltrials.gov/ct2/show/NCT03459079

IVA-337 (LANIFIBRANOR), an indole sulfonamide derivative, is a pan peroxisome proliferator-activated receptor (PPAR) agonist. It is under investigation in Phase 2 clinical trials for non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, and type 2 diabetes.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor alpha 62 Target ID: Q07869 Gene ID: 5465.0 Gene Symbol: PPARA Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29446942 \| http://inventivapharma.com/pipeline/lanifibranor	Agonist 2752
Peroxisome proliferator-activated receptor delta 30 Target ID: Q03181\|\|\|Q9BUD4 Gene ID: 5467.0 Gene Symbol: PPARD Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29446942 \| http://inventivapharma.com/pipeline/lanifibranor	Agonist 2752
Peroxisome proliferator-activated receptor gamma 118 Target ID: P37231\|\|\|Q15179 Gene ID: 5468.0 Gene Symbol: PPARG Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29446942 \| http://inventivapharma.com/pipeline/lanifibranor	Agonist 2752

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

800 mg/day.

Route of Administration: Oral

In Vitro Use Guide

LANIFIBRANOR (IVA-337) is a pan peroxisome proliferator-activated receptor (PPAR) agonist with EC50s of 1.5, 0.87 and 0.21 uM for human PPARa, PPARb and PPARg, respectively.

Name

Type

Language

lanifibranor [INN]

Preferred Name

English

LANIFIBRANOR

Official Name

English

Lanifibranor [WHO-DD]

Common Name

English

1H-INDOLE-2-BUTANOIC ACID, 1-(6-BENZOTHIAZOLYLSULFONYL)-5-CHLORO-

Systematic Name

English

IVA-337

Code

English

5-CHLORO-1-((6-BENZOTHIAZOLYL)SULFONYL)-1H-INDOLE-2-BUTANOIC ACID

Systematic Name

English

4-(1-(1,3-BENZOTHIAZOL-6-YLSULFONYL)-5-CHLORO-INDOL-2-YL)BUTANOIC ACID

Systematic Name

English

IVA337

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

470315