Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H22N4O4S2 |
| Molecular Weight | 458.554 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)S(=O)(=O)C1=C(OCCO)C=C2N=CN=C(NC3=CC4=C(SC=N4)C=C3)C2=C1
InChI
InChIKey=UHDOJINBFLDQJM-UHFFFAOYSA-N
InChI=1S/C21H22N4O4S2/c1-21(2,3)31(27,28)19-9-14-15(10-17(19)29-7-6-26)22-11-23-20(14)25-13-4-5-18-16(8-13)24-12-30-18/h4-5,8-12,26H,6-7H2,1-3H3,(H,22,23,25)
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
314.2321 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
351.0316 ng/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2717.46 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2950.11 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
104.28 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
257.28 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
405.39 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
911.53 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
30 mg single, oral dose: 30 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2860.23 ng × h/mL CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
10.48 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
9.526 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
7.044 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
8.304 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
9.649 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
8.717 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
30 mg single, oral dose: 30 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
9.799 h CLINICAL TRIAL https://clinicaltrials.gov/study/NCT03358407?tab=results |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
GSK-2983559 ACTIVE METABOLITE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
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2893X36L7K
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71258526
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1423186-80-4
Created by
admin on Wed Apr 02 20:34:19 GMT 2025 , Edited by admin on Wed Apr 02 20:34:19 GMT 2025
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PRODRUG (METABOLITE ACTIVE)
SUBSTANCE RECORD
