Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H26N2O4 |
| Molecular Weight | 382.4528 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H]([C@H](CN1CC[C@]23C(=O)NC4=CC=CC=C34)C=C)C(=C/OC)\C(=O)OC
InChI
InChIKey=MUVGVMUWMAGNSY-KAXDATADSA-N
InChI=1S/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24522518
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24522518
Corynoxeine is a compound isolated from Uncaria rhynchophylla, a traditional Chinese herb that has been applied to the treatment of convulsive disorders in China. Corynoxeine was found to inhibit PDGF-BB-induced activation of ERK1/2 and vascular smooth muscle cells proliferation. Corynoxeine found to induce autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells and may have potential application for the prevention or treatment of Parkinson's disease.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. | 2008 Nov |
|
| The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan. | 2011 Jul |
|
| Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. | 2014 Jun |
Patents
Sample Use Guides
In a rat PK study, Yokukansan (a traditional Japanese medicine, containing corynoxeine) was administered orally at 1 or 4 g/kg.
Route of Administration:
Oral
Vascular smooth muscle cells (VSMCs) were seeded in 12-well culture plates at 5x104 cells/ml and cultured in DMEM with 10% FBS at 37 °C for 24 h. Under these conditions, the cells reached ca. 70% confluence. VSMCs were pre-cultured in serum-free medium in the presence and absence of corynoxeine (5 - 50mM) for 24 h and then stimulated with 50 ng/ml PDGF-BB. The cells were trypsinized and counted using hemocytometer after 24 h.
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DTXSID001318311
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27KIC0Q2VA
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27KIC0Q2VA
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2562545
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630-94-4
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44568160
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SUBSTANCE RECORD
