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Details

Stereochemistry ACHIRAL
Molecular Formula C16H16O3
Molecular Weight 256.297
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PTEROSTILBENE

SMILES

COc1cc(/C(/[H])=C(\[H])/c2ccc(cc2)O)cc(c1)OC

InChI

InChIKey=VLEUZFDZJKSGMX-ONEGZZNKSA-N
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

HIDE SMILES / InChI
Pterostilbene is a naturally derived compound found primarily in blueberries and Pterocarpus marsupium heartwood. The multiple benefits of pterostilbene in the treatment and prevention of human disease have been attributed to its antioxidant, anti-inflammatory, and anti-carcinogenic properties leading to improved function of normal cells and inhibition of malignant cells. The antioxidant activity of pterostilbene has been implicated in anti-carcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. Pterostilbene increases LDL and reduces blood pressure in adults. Low doses of pterostilbene seem to hold some benefit for cognition.

Originator

Sources: DOI: 10.1016/S0031-9422(00)88430-7

Approval Year

Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis.
2008 Jun
Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.
2013 Feb 8
The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay.
2013 Oct
Involvement of the Nrf2 pathway in the regulation of pterostilbene-induced apoptosis in HeLa cells via ER stress.
2014
Proteomic identification of pterostilbene-mediated anticancer activities in HepG2 cells.
2014 Jul 21
Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2.
2016 Jan 19
Patents

Sample Use Guides

50 mg or 125 mg twice daily for 6-8 weeks
Route of Administration: Oral
Pterostilbene inhibited the growth of normal fibroblasts in a dose-dependent manner similar to resveratrol (IC50 60 uM for both), and pterostilbene also caused cell cycle imbalance in a manner similar to that of resveratrol.
Name Type Language
PTEROSTILBENE
WHO-DD  
Common Name English
PTEROSTILBENE [WHO-DD]
Common Name English
PHENOL, 4-((1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL)-
Systematic Name English
3,5-DIMETHOXY-4'-HYDROXY-TRANS-STILBENE
Systematic Name English
EH-301 COMPONENT PTEROSTILBENE
Common Name English
TRANS-PTEROSTILBENE
Common Name English
PTEROSTILBENE, (E)-
Common Name English
4-((1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL)PHENOL
Systematic Name English
TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE
Systematic Name English
Classification Tree Code System Code
DSLD 1717 (Number of products:177)
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
FDA ORPHAN DRUG 628218
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
NCI_THESAURUS C275
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
Code System Code Type Description
FDA UNII
26R60S6A5I
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY
WIKIPEDIA
Pterostilbene
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY
CAS
18259-15-9
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
NON-SPECIFIC STEREOCHEMISTRY
EPA CompTox
537-42-8
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY
CAS
537-42-8
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY
NCI_THESAURUS
C153353
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY
PUBCHEM
5281727
Created by admin on Sat Jun 26 01:35:21 UTC 2021 , Edited by admin on Sat Jun 26 01:35:21 UTC 2021
PRIMARY