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Details

Stereochemistry RACEMIC
Molecular Formula C21H36NO.Cl
Molecular Weight 353.97
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIDIHEXETHYL CHLORIDE

SMILES

[Cl-].CC[N+](CC)(CC)CCC(O)(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=XJGONMZLEDGBRM-UHFFFAOYSA-M
InChI=1S/C21H36NO.ClH/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI
Tridihexethyl is a synthetic anticholinergic agent which was marketed under the brand name Pathilon as an adjunct in the treatment of peptic ulcer disease. However, it is no longer available in the US market. Tridihexethyl may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart, and M-3 receptors. The muscarinic acetylcholine receptors mediate various cellular responses including inhibition of adenylate cyclase, the breakdown of phosphoinositides, and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This, in turn, reduces the secretion of gastric acids in the stomach. Tridihexethyl was also examined for effect on patients with acquired nystagmus where four out of six patients showed improvement, but due to the profile usage of Tridihexethyl to treat nystagmus was limited.

Approval Year

PubMed

PubMed

TitleDatePubMed
Influence of the anticholineric drug pathilon on the reproductive cycle of the female rat.
1958 Apr
Results of treatment of gastric and gastroduodenal ulcer with trepidon-pathilon.
1962
Transient visual anomalies associated with drug treatment for spastic colon.
1986 Aug
Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride.
1991 Nov
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Parenteral
In Vitro Use Guide
Unknown
Name Type Language
TRIDIHEXETHYL CHLORIDE
MART.   ORANGE BOOK   USP-RS   VANDF   WHO-DD  
Common Name English
BENZENEPROPANAMINIUM, .GAMMA.-CYCLOHEXYL-N,N,N-TRIETHYL-.GAMMA.-HYDROXY-, CHLORIDE
Systematic Name English
TRIDIHEXETHYL CHLORIDE [VANDF]
Common Name English
PATHILON
Brand Name English
TRIDIHEXETHYL CHLORIDE [MART.]
Common Name English
TRIDIHEXETHYL IODIDE TRIDIHEXETHYL CHLORIDE [MI]
Common Name English
Tridihexethyl chloride [WHO-DD]
Common Name English
TRIDIHEXETHYL CHLORIDE [ORANGE BOOK]
Common Name English
(3-Cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium chloride
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
224-323-3
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PRIMARY
CHEBI
9703
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
PRIMARY
NCI_THESAURUS
C66632
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
PRIMARY
SMS_ID
100000077275
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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PUBCHEM
20298
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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EVMPD
SUB15610MIG
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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CAS
4310-35-4
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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FDA UNII
25YK75CYMX
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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DRUG BANK
DBSALT001377
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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EPA CompTox
DTXSID4023701
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
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MERCK INDEX
m11096
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
PRIMARY Merck Index
RXCUI
54421
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL1201354
Created by admin on Fri Dec 15 16:17:43 GMT 2023 , Edited by admin on Fri Dec 15 16:17:43 GMT 2023
PRIMARY