PENFLURIDOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H27ClF5NO
Molecular Weight	523.965
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC=C(Cl)C(=C4)C(F)(F)F

InChI

InChIKey=MDLAAYDRRZXJIF-UHFFFAOYSA-N

InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6408670

Penfluridol is a highly potent; first generation diphenylbutylpiperidine antipsychotic was developed by Janssen Pharmaceutica in 1968 and is used to treat schizophrenial and similar psychotic disorders. It is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. This drug is long-acting dopamine receptor blocker.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine receptor 60 Target ID: CHEMBL2096905 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6408670	Blocker 555

Conditions

Condition	Modality	Targets	Highest Phase	Product
Psychotic disorder 26 Sources: http://www.medindia.net/doctors/drug_information/penfluridol.htm	Primary		Approved 8583	Unknown Approved Use Unknown
Schizophrenia 305 Sources: http://www.medindia.net/doctors/drug_information/penfluridol.htm	Primary		Approved 8583	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
140 mg 1 times / week multiple, oral Studied dose Dose: 140 mg, 1 times / week Route: oral Route: multiple Dose: 140 mg, 1 times / week Sources: https://pubmed.ncbi.nlm.nih.gov/7107969/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/7107969/	Sources: https://pubmed.ncbi.nlm.nih.gov/7107969/

PubMed

Title	Date	PubMed
The position of mefloquine as a 21st century malaria chemoprophylaxis.	2010-12-09	21143906
Research on antipsychotics in India.	2010-01	21836703
An overview of Indian research in schizophrenia.	2010-01	21836674
Antipsychotics and risk of venous thromboembolism: A population-based case-control study.	2009-08-09	20865083
Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches.	2007	17726915
Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review.	2006-09	17017818
Penfluridol for schizophrenia.	2006-04-19	16625563
Brief psychotic disorder associated with Sturge-Weber syndrome.	2005-06	16018933
Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study.	2005-03	15766297
An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1.	2002-12-20	12368289
LC-MS-MS analysis of the neuroleptics clozapine, flupentixol, haloperidol, penfluridol, thioridazine, and zuclopenthixol in hair obtained from psychiatric patients.	2002-08-09	12166818
Differential inhibition of T-type calcium channels by neuroleptics.	2002-01-15	11784784
Comparative short-term evaluation of penfluridol and trifluoperazine in chronic schizophrenia.	1988-10-01	3063660
[Pharmacological studies of antipsychotic drug, penfluridol. 2. General pharmacological properties].	1976-07	1033105

Patents

Sample Use Guides

In Vivo Use Guide

Initial: 20-60 mg/week. Severe/resistant: ≤250 mg/week.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

SEMAP

Preferred Name

English

PENFLURIDOL

Official Name

English

1-(4,4-BIS(P-FLUOROPHENYL)BUTYL)-4-(4-CHLORO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)-4-PIPERIDINOL

Common Name

English

Penfluridol [WHO-DD]

Common Name

English

PENFLURIDOL [JAN]

Common Name

English

R 16,341

Code

English

4-PIPERIDINOL, 1-(4,4-BIS(4-FLUOROPHENYL)BUTYL)-4-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)-

Systematic Name

English

MCN-JR-16341

Code

English

PENFLURIDOL [USAN]

Common Name

English

PENFLURIDOL [MART.]

Common Name

English

MCN-JR-16,341

Code

English

R-16341

Code

English

penfluridol [INN]

Common Name

English

NSC-759179

Code

English

PENFLURIDOL [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883