Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H38N.I |
Molecular Weight | 431.4376 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[I-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1
InChI
InChIKey=KQVYBYSUVFRMGE-UHFFFAOYSA-M
InChI=1S/C21H38N.HI/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;/h15,17-18,20-21H,2-14,16,19H2,1H3;1H/q+1;/p-1
Cetylpyridinium (used in a form of chloride salt) is a cationic surface-active agent and has a broad antimicrobial spectrum, with rapid killing of gram-positive pathogens and yeast in particular. It is suggested that interaction with bacteria occurs by the disruption of membrane function, leakage of cytoplasmic material, and ultimately the collapse of the intra-cellular equilibrium. The drug is used under various trade names as an oral OTC hygiene product (mouthwash, dental kits, etc.) to control the dental plaque and to prevent the subsequent gingivitis.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Bacterial membrane Sources: https://www.ncbi.nlm.nih.gov/pubmed/19138180 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | ANTISEPTIC (cetylpyridinium chloride) mouthwash Approved UseHelp to control plaque that leads to gingivitis. |
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Curative | ANTISEPTIC (cetylpyridinium chloride) mouthwash Approved UseHelp to control plaque that leads to gingivitis. |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
10 mg/g EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16477395/ |
6 μL single, topical dose: 6 μL route of administration: Topical experiment type: SINGLE co-administered: |
CETYLPYRIDINIUM unknown | Mus musculus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
127 mg × h/g EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/16477395/ |
6 μL single, topical dose: 6 μL route of administration: Topical experiment type: SINGLE co-administered: |
CETYLPYRIDINIUM unknown | Mus musculus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
PubMed
Title | Date | PubMed |
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Effect of dental unit waterline biocides on enamel bond strengths. | 2001 Jul-Aug |
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Evaluation of the bactericidal activity of povidone-iodine and commercially available gargle preparations. | 2002 |
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Solubility, chemical and photochemical stability of curcumin in surfactant solutions. Studies of curcumin and curcuminoids, XXVIII. | 2002 Dec |
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[The simultaneous determination of iron(III) and aluminium(III) in quartz sand by first derivative spectrophotometry]. | 2002 Feb |
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[Prospect of the development of new bactericidal drugs against Helicobacter pylori for eradication therapy]. | 2002 Feb |
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The effect of four mouthrinses on oral malodor. | 2002 Jun |
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A method to compare four mouthrinses: time to gingivitis level as the primary outcome variable. | 2002 Jun |
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Cysteine challenge testing: a powerful tool for examining oral malodour processes and treatments in vivo. | 2002 Jun |
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Visible absorption spectra of the 4f electron transitions of neodymium, praseodymium, holmium and erbium complexes with fleroxacin and their analytical application. | 2002 May |
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Buccoadhesive erodible disk for treatment of oro-dental infections: design and characterisation. | 2002 May 15 |
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Determination of chondroitin sulfate in raw materials by liquid chromatography. | 2002 May-Jun |
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Thermodynamics and micellar properties of tetradecyltrimethylammonium bromide in formamide-water mixtures. | 2002 Nov 15 |
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Effects of various antiplaque agents on fructosyltransferase activity in solution and immobilized onto hydroxyapatite. | 2002 Oct |
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Glycosaminoglycan blotting on nitrocellulose membranes treated with cetylpyridinium chloride after agarose-gel electrophoretic separation. | 2002 Sep |
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Evaluation of culture media for the recovery of Mycobacterium avium subsp. paratuberculosis from Cheddar cheese. | 2003 |
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Comparative evaluation of the MGIT and BACTEC culture systems for the recovery of Mycobacterium avium subsp. paratuberculosis from milk. | 2003 |
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[Delmopinol--an alternative to chlorhexidine?]. | 2003 |
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Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: an in vitro contact test and salivary bacterial counts study. | 2003 Apr |
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Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. | 2003 Apr |
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Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid. | 2003 Apr 14 |
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Combined effect of zinc ions and cationic antibacterial agents on intraoral volatile sulphur compounds (VSC). | 2003 Aug |
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Examination of murine tear film. | 2003 Aug |
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Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas. | 2003 Aug |
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A rapid procedure to ascertain the antimicrobial efficacy of oral care formulations. | 2003 Dec |
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Isolation of intact aortic valve scaffolds for heart-valve bioprostheses: extracellular matrix structure, prevention from calcification, and cell repopulation features. | 2003 Dec 15 |
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Reduction of poliovirus 1, bacteriophages, Salmonella montevideo, and Escherichia coli O157:H7 on strawberries by physical and disinfectant washes. | 2003 Feb |
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Dissolved organic matter effects on the performance of a barrier to polycyclic aromatic hydrocarbon transport by groundwater. | 2003 Feb |
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An in vitro evaluation of the availability of cetylpyridinium chloride and chlorhexidine in some commercially available mouthrinse products. | 2003 Feb 22 |
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Comparative study on fluorescence enhancement and quenching of europium and terbium chelate anions in cationic micelles. | 2003 Jan 15 |
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Inactivation kinetics of mushroom tyrosinase by cetylpyridinium chloride. | 2003 Jul |
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A salivary incubation test for evaluation of oral malodor: a pilot study. | 2003 Jul |
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Spectrophotometric method for the determination of manganese with phenylfluorone in the presence of Triton X-100 and cetylpyridinium chloride in pharmacological preparations and vegetable fertilizers. | 2003 Jul |
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Purification of sulfated fucoglucuronomannan lyase from bacterial strain of Fucobacter marina and study of appropriate conditions for its enzyme digestion. | 2003 Jul-Aug |
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Impact of brief exposure to balanced salts solution or cetylpyridinium chloride on the surface appearance of the rabbit corneal epithelium--a scanning electron microscopy study. | 2003 Jun |
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Determination of cetylpyridinium chloride and tetracaine hydrochloride in buccal tablets by RP-HPLC. | 2003 Jun 1 |
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Effect of toothpaste on the plaque inhibitory properties of a cetylpyridinium chloride mouth rinse. | 2003 Mar |
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Utility of formazans and cetylpyridinium chloride in rapid spectrophotometric determination of zinc in biological materials and pharmaceutical formulations. | 2003 Mar 10 |
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Cooling towers--a potential environmental source of slow-growing mycobacterial species. | 2003 Mar-Apr |
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Inhibitory effects on selected oral bacteria of antibacterial agents incorporated in a glass ionomer cement. | 2003 Mar-Apr |
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Evaluation of cetylpyridinium chloride for infection control in storage solution. | 2003 May |
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Direct and specific recognition of glycosaminoglycans by antibodies after their separation by agarose gel electrophoresis and blotting on cetylpyridinium chloride-treated nitrocellulose membranes. | 2003 May |
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The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study. | 2003 May |
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Modification of ion chromatographic separations by ionic and nonionic surfactants. | 2003 May 16 |
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[DNA complexes, formed on aqueous phase surfaces: new planar polymeric and composite nanostructures]. | 2003 Nov-Dec |
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The effect of antimicrobial pre-treatments on the performance of resin composite restorations. | 2003 Nov-Dec |
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Reversible and irreversible adsorption of surfactants at a hanging mercury drop electrode. | 2003 Oct |
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A standardized test to assess the impact of different organic challenges on the antimicrobial activity of antiseptics. | 2003 Oct |
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Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride--effect of concentration. | 2003 Oct |
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Soft antimicrobial agents: synthesis and activity of labile environmentally friendly long chain quaternary ammonium compounds. | 2003 Sep 11 |
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Quenching of fluorescence of 1-hydroxypyrene-3,6,8-trisulfonate (HPTS) by Cu2+, Co2+, Ni2+, I-, and cetylpyridinium (CP+) ions in water/AOT/heptane microemulsion. | 2004 Mar 1 |
Sample Use Guides
Rinse for 30 seconds with 20 ml (4 teaspoonsfuls) twice a day, do not swallow.
Route of Administration:
Dental
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23039819
The panel of 24 laboratory strains including 18 oral bacteria, five nonoral bacterialspecies and the yeast Candida albicans was incubated with twofold serial dilutions of the 0.05% cetylpyridinium chloride mouthrinse for 48-72 h at 35 celsius degrees. For the agar dilution assays of cultivable plaque bacte-ria, the drug was added at a final concentration of 1%. MIC values were 1.5-3% for Aggregatibacter actinomycetemcomitans and Capnocytophaga gingivalis, 0.375% for Actinomyces meyeri, Moraxella catarrhalis, Campylobacter rectus, 0.187-0.375 % for Porphyromonas gingivalis, etc.
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14918987
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DTXSID70565393
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ACTIVE MOIETY
SUBSTANCE RECORD