Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H12N3O14P3.2Na.2H.2H2O |
| Molecular Weight | 563.1505 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].O.O.[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O
InChI
InChIKey=KNSYTSUGTLJHPS-ODQFIEKDSA-L
InChI=1S/C9H16N3O14P3.2Na.2H2O/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;;2*1H2/q;2*+1;;/p-2/t4-,6-,7-,8-;;;;/m1..../s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes. | 2004-07 |
|
| Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP. | 2004-06-01 |
|
| Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets. | 2004-06-01 |
|
| Expression of the pyrG gene determines the pool sizes of CTP and dCTP in Lactococcus lactis. | 2004-06 |
|
| Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. | 2004-05-01 |
|
| Competition between ammonia derived from internal glutamine hydrolysis and hydroxylamine present in the solution for incorporation into UTP as catalysed by Lactococcus lactis CTP synthase. | 2004-04-01 |
|
| Antiretroviral pipeline: new-drug reports from retroviruses conference. | 2004-02-27 |
|
| Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss. | 2004-01-15 |
|
| A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state. | 2004-01-09 |
|
| Control of pyrimidine biosynthesis in "Pseudomonas alkanolytica" ATCC 21034. | 2004 |
|
| Regeneration of cofactors for use in biocatalysis. | 2003-12 |
|
| Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1. | 2003-12 |
|
| Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. | 2003-11-03 |
|
| Characterisation of Pt MYB1, an R2R3-MYB from pine xylem. | 2003-11 |
|
| Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. | 2003-11 |
|
| Incorporation of (alpha-P-borano)-2',3'-dideoxycytidine 5'-triphosphate into DNA by drug-resistant MMLV reverse transcriptase and Taq DNA polymerase. | 2003-10-21 |
|
| Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. | 2003-10-17 |
|
| Trapping specific quaternary states of the allosteric enzyme aspartate transcarbamoylase in silica matrix sol-gels. | 2003-08-20 |
|
| Fold recognition, homology modeling, docking simulations, kinetics analysis and mutagenesis of ATP/CTP:tRNA nucleotidyltransferase from Methanococcus jannaschii. | 2003-08-15 |
|
| Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm-cpn. | 2003-07-17 |
|
| [Research on motor dysfunction and the role of CTP after traumatic brain injury in rats]. | 2003-07 |
|
| Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae. | 2003-06-06 |
|
| Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses. | 2003-05-23 |
|
| Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha. | 2003-05-06 |
|
| Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis. | 2003-05 |
|
| In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 3. Influences of individual DNA elements within the promoter recognition region on abortive initiation and promoter escape. | 2003-04-08 |
|
| In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 2. Formation and characterization of two distinct classes of initial transcribing complexes. | 2003-04-08 |
|
| In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 1. RNA chain initiation, abortive initiation, and promoter escape at three bacteriophage promoters. | 2003-04-08 |
|
| Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. | 2003-04-04 |
|
| CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values. | 2003-03-21 |
|
| Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. | 2003-03 |
|
| NTP pattern of avian embryonic red cells: role of RNA degradation and AMP deaminase/5'-nucleotidase activity. | 2003-03 |
|
| Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis. | 2003-02-28 |
|
| Neighbouring bases in template influence base-pairing of isoguanine. | 2003-02-01 |
|
| Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase. | 2003-02-01 |
|
| Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. | 2003-02 |
|
| HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset). | 2003-01 |
|
| Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV. | 2003-01 |
|
| Iodine-125 radioprobing of E. coli RNA polymerase transcription elongation complexes. | 2003 |
|
| The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase. | 2002-12-20 |
|
| Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. | 2002-12-13 |
|
| Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation. | 2002-12-06 |
|
| Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase. | 2002-12 |
|
| Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors. | 2002-11 |
|
| Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis. | 2002-10 |
|
| Differential processing of the Xenopus ATP(CTP):tRNA nucleotidyltransferase mRNA. | 2002-09-27 |
|
| An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography. | 2002-09-15 |
|
| [Preliminary clinical study of application of cyntridini triphosphatis and dexamethasone in treatment of sudden deafness]. | 2002-08 |
|
| The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein. | 2002-07-17 |
|
| On-line microdialysis for enhanced resolution and sensitivity during electrospray mass spectrometry of non-covalent complexes and competitive binding studies. | 2002 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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257277ZO3K
Created by
admin on Mon Mar 31 23:24:53 GMT 2025 , Edited by admin on Mon Mar 31 23:24:53 GMT 2025
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2724340
Created by
admin on Mon Mar 31 23:24:53 GMT 2025 , Edited by admin on Mon Mar 31 23:24:53 GMT 2025
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PRIMARY | |||
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81012-87-5
Created by
admin on Mon Mar 31 23:24:53 GMT 2025 , Edited by admin on Mon Mar 31 23:24:53 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
