OROTIRELIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H19N7O5
Molecular Weight	389.366
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)C3=CC(=O)NC(=O)N3

InChI

InChIKey=XZOCIZHAHWDUPU-QWRGUYRKSA-N

InChI=1S/C16H19N7O5/c17-13(25)11-2-1-3-23(11)15(27)10(4-8-6-18-7-19-8)20-14(26)9-5-12(24)22-16(28)21-9/h5-7,10-11H,1-4H2,(H2,17,25)(H,18,19)(H,20,26)(H2,21,22,24,28)/t10-,11-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2470455 | https://www.ncbi.nlm.nih.gov/pubmed/2503226

Orotirelin (previously known as CG 3509) was investigated as a thyrotropin-releasing hormone. Experiments on rats have shown that compound could increase dopamine release from rodent brain. Information about the current study of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Involvement of catecholaminergic neurones and alpha-adrenoceptors in the wet-dog shake and forepaw licking behaviour produced by the intrathecal injection of an analogue of thyrotrophin-releasing hormone (CG 3509).	1987 Aug	2889164

Name

Type

Language

OROTIRELIN

Official Name

English

N-((1,2,3,6-TETRAHYDRO-2,6-DIOXO-4-PYRIMIDINYL)CARBONYL)-L-HISTIDYL-L-PROLINAMIDE

Systematic Name

English

CG-3509

Common Name

English

orotirelin [INN]

Common Name

English

CG3509

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C76367