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Details

Stereochemistry ACHIRAL
Molecular Formula Na.O3V
Molecular Weight 121.9295
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM METAVANADATE

SMILES

[Na+].[O-][V](=O)=O

InChI

InChIKey=CMZUMMUJMWNLFH-UHFFFAOYSA-N
InChI=1S/Na.3O.V/q+1;;;-1;

HIDE SMILES / InChI
There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.

CNS Activity

Curator's Comment: Known to be CNS penetrant in mouse. Human data not available blood-brain barrier disruption

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms.
1998 Aug
Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: a mitogen for lung fibroblasts.
2001 Feb
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
2002 Oct
Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.
2003 May
Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ.
2006 Nov 29
Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis.
2007 Apr 25
STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop.
2008 Mar 15
Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals.
2009 Dec
Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.
2009 Oct 15
Patents

Sample Use Guides

toxicity study: Female F344 rats and B6C3F1 mice were exposed to vanadium pentoxide (V2O5) at concentrations of 0, 0.5, 1, or 2 mg/m3 (rats) and 0, 1, 2, or 4 mg/m3 (mice) for 6 h/day, 5 days/week (for up to 18 months), by whole-body inhalation.
Route of Administration: Respiratory
It was study to evaluate the effect of vanadium pentoxide (V2O5) on endothelial cells since they are key participants in the pathogenesis of several cardiovascular and inflammatory diseases. Cell adhesion, the expression of adhesion molecules and oxidative stress, as well as proliferation, morphology and cell death of human umbilical vein endothelial cells (HUVECs) exposed to V2O5, were evaluated. Vanadium pentoxide at a 3.12 µg cm(-2) concentration induced an enhanced adhesion of the U937 macrophage cell line to HUVECs, owing to an increased expression of late adhesion molecules. HUVECs exposed to V2O5 showed an increase in ROS and nitric oxide production, and a diminished proliferation. These changes in vanadium-treated HUVECs were accompanied by severe morphological changes and apoptotic cell death. Vanadium pentoxide induced serious endothelial cell damage, probably related to the increased cardiovascular morbidity and mortality observed in individuals living in highly air-polluted areas.
Name Type Language
SODIUM METAVANADATE
MI   WHO-DD  
Common Name English
NSC-79535
Code English
Sodium Metavanadate [WHO-DD]
Common Name English
VANADATE (VO31-), SODIUM (1:1)
Common Name English
SODIUM METAVANADATE [MI]
Common Name English
SODIUM VANADIUM TRIOXIDE
Common Name English
SODIUM VANADATE
Common Name English
SODIUM VANADATE(V)
Common Name English
SODIUM TRIOXOVANADATE
Common Name English
Classification Tree Code System Code
DSLD 3866 (Number of products:1)
Created by admin on Fri Dec 15 21:32:31 GMT 2023 , Edited by admin on Fri Dec 15 21:32:31 GMT 2023
Code System Code Type Description
EVMPD
SUB22097
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PRIMARY
WIKIPEDIA
SODIUM METAVANADATE
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MERCK INDEX
m10044
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PRIMARY Merck Index
NSC
79535
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DRUG BANK
DB14702
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CAS
13718-26-8
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CHEBI
75221
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CHEBI
35607
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SMS_ID
100000085612
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PUBCHEM
4148882
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ECHA (EC/EINECS)
237-272-7
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EPA CompTox
DTXSID3044336
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FDA UNII
252S9L5606
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