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Details

Stereochemistry ACHIRAL
Molecular Formula C24H31NO4.ClH
Molecular Weight 433.968
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of DROTAVERINE HYDROCHLORIDE

SMILES

Cl.CCOC1=CC=C(\C=C2/NCCC3=CC(OCC)=C(OCC)C=C23)C=C1OCC

InChI

InChIKey=JBFLYOLJRKJYNV-MASIZSFYSA-N
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;

HIDE SMILES / InChI
Drotaverine, an antispasmodic drug, is a synthetic derivative of the natural isoquinoline alkaloid of Papaver somniferum, papaverine. It inhibits cyclic-3',5'-nucleotide-phophodiesterase (PDE) enzymes with concentration-dependent specificity, in addition, it behaves as a L-type voltage- operated calcium channel (L-VOCC) blocker. Drotaverin also acts as a cytostatic compound for several human tumor cell lines. Drotaverine is an effective medicine to treat spasm or twitches of the smooth muscles in the stomach and heart. It is used to relieve pain caused due to irritable bowel syndrome, headache, menstrual periods, and is also used to relieve cervical spasm during labor.

Approval Year

Targets
PubMed

PubMed

TitleDatePubMed
Pharmacokinetics and bioavailability of drotaverine in humans.
1996 Jul-Sep
[Acute intermittent porphyria and oral contraception. Case report].
2006 Mar
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
2010 Dec
Patents

Sample Use Guides

The drug is administered for interior use. 1-2 tablets (0.04—0.08 g) 2—3 time a day. In children under 6 0.01—0.02 g 1—2 times a day, in children of 6—12 years old — 0.02 g 1—2 times a day. In children after 12 the adult dose.
Route of Administration: Oral
Drotaverin also acts as a cytostatic compound for several human tumor cell lines and nonmalignant mouse fibroblasts, and EC50 values as low as 3.0 μM were observed in SRB assays for HT-29 human colorectal carcinoma cells.
Name Type Language
DROTAVERINE HYDROCHLORIDE
MI   WHO-DD  
Common Name English
DROTAVERINE HCL
Common Name English
ISODIHYDROPERPARINE HYDROCHLORIDE
Common Name English
(Z)-1-(3,4-DIETHOXYBENZYLIDENE)-6,7-DIETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
Systematic Name English
DROTAVERINE HYDROCHLORIDE [MI]
Common Name English
Drotaverine hydrochloride [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
NCI_THESAURUS C29698
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID40243590
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
EVMPD
SUB01843MIG
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
PUBCHEM
6437861
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
DRUG BANK
DB06751
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
RXCUI
236960
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m4773
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY Merck Index
SMS_ID
100000087720
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
NCI_THESAURUS
C97980
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
CAS
985-12-6
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY
FDA UNII
24ZVH4C669
Created by admin on Sat Dec 16 05:13:23 GMT 2023 , Edited by admin on Sat Dec 16 05:13:23 GMT 2023
PRIMARY