ISAMOXOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H20N2O2
Molecular Weight	224.2994
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCN(C(=O)C(C)C)C1=NC(C)=CO1

InChI

InChIKey=VMBNXRJYPJRJIU-UHFFFAOYSA-N

InChI=1S/C12H20N2O2/c1-5-6-7-14(11(15)9(2)3)12-13-10(4)8-16-12/h8-9H,5-7H2,1-4H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67017436 | https://www.ncbi.nlm.nih.gov/pubmed/6781575

ISAMOXOLE is an effective anti-allergic compound in animals. It is a moderately potent, selective inhibitor of slow-reacting substance of anaphylaxis (SRS-A) activity. SRS-A is a group of leukotrienes (LTC4, LTD4, and LTE4) that is the major mediator of bronchoconstriction, hypersensitivity, and other allergic reactions.

Approval Year

PubMed

Title	Date	PubMed
The metabolism of isamoxole in the rat and guinea-pig.	1979 Oct	532211
The pharmacology of isamoxole [2-methyl-n-butyl-n(4-methyloxazol-2-yl) propanamide] LRCL 3950, a new anti-allergic compound.	1980	6781575
Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.	1983 Jun	6412526

Patents

Name

Type

Language

ISAMOXOLE

Official Name

English

COMPOUND-90606

Code

English

isamoxole [INN]

Common Name

English

COMPOUND 90606

Code

English

PROPANAMIDE, N-BUTYL-2-METHYL-N-(4-METHYL-2-OXAZOLYL)-

Systematic Name

English

ISAMOXOLE [USAN]

Common Name

English

NSC-301203

Code

English

N-Butyl-2-methyl-N-(4-methyl-2-oxazolyl)propionamide

Systematic Name

English

Code System Code Type Description

FDA UNII

24QIB5VSGX