Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Al.O7Si2.2H2O |
| Molecular Weight | 258.1604 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Al+3].[Al+3].[O-][Si]([O-])([O-])O[Si]([O-])([O-])[O-]
InChI
InChIKey=KGOIAFZMMLWXLM-UHFFFAOYSA-N
InChI=1S/2Al.O7Si2.2H2O/c;;1-8(2,3)7-9(4,5)6;;/h;;;2*1H2/q2*+3;-6;;
Kaolin is a hydrated aluminum silicate mineral. It occurs naturally as a clay that is prepared for pharmaceutical purposes by washing with water to remove sand and other impurities. Kaolin has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac lesions. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash. Kaolin is used in medicine as an activator of intrinsic pathway of coagulation in an aPPT test.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P00748 Gene ID: 2161.0 Gene Symbol: F12 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseKaolin is used for mild-to-moderate diarrhea, severe diarrhea (dysentery), and cholera. |
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| Primary | Unknown Approved UseKaolin has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac lesions. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash. |
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| Primary | Unknown Approved UseIn combination products, kaolin is used to treat diarrhea and to relieve soreness and swelling inside the mouth caused by radiation treatments. |
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| Primary | Unknown Approved UseIn combination products, kaolin is used to treat diarrhea and to relieve soreness and swelling inside the mouth caused by radiation treatments. Some of these combination products are used for treating ulcers and swelling (inflammation) in the large intestine (chronic ulcerative colitis). |
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| Palliative | Unknown Approved UseAntidiarrheal preparations containing kaolin have been used in the treatment of enteritis, cholera, and dysentery. Kaolin preparations, however, have no intrinsic antibacterial activity and should not be used as the sole treatment in infectious diarrheas. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activation of Hageman factor (factor XII) by sulfatides and other agents in the absence of plasma proteases. | 1983 Jul |
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| Experimental study on subacute neurotoxicity of methotrexate in cats. | 1989 |
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| Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. | 1999 Sep |
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| Chronopharmacology of morphine in mice. | 2005 |
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| Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala. | 2007 Jun |
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| Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2013 Jan |
Patents
Sample Use Guides
Diarrhea: 12 years of age and older: 26.2 g after each loose stool every 6 hours until firm stool; do not exceed more than 262 g per 24 hours; do not use longer than 2 days. Diaper rash: 4% to 20% kaolin-containing products applied topically. Radiation- and chemotherapy-induced mucositis: 15 mL of kaolin/pectin and diphenhydramine in a 50:50 mixture; hold in mouth for 3 minutes. For treatment of cholera, kaolin is administered orally or by rectum.
Route of Administration:
Other
In an APPT test platelet poor plasma [PPP] is incubated at 37°C with phospholipid (cephalin) and a contact activator (Kaolin) is added followed by the calcium (all pre-warmed to 37°C). Addition of calcium initiates clotting and timing begins. The APTT is the time taken for a fibrin clot to form. Initial incubation times may vary from 2-10 minutes.
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WHO-VATC |
QA07BC02
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CFR |
21 CFR 178.3297
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CFR |
21 CFR 347.10
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CFR |
21 CFR 335.50
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CFR |
21 CFR 186.1256
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admin on Fri Dec 15 16:14:54 UTC 2023 , Edited by admin on Fri Dec 15 16:14:54 UTC 2023
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EPA PESTICIDE CODE |
100103
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admin on Fri Dec 15 16:14:54 UTC 2023 , Edited by admin on Fri Dec 15 16:14:54 UTC 2023
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CFR |
21 CFR 335.10
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admin on Fri Dec 15 16:14:54 UTC 2023 , Edited by admin on Fri Dec 15 16:14:54 UTC 2023
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WHO-ATC |
A07BC02
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admin on Fri Dec 15 16:14:54 UTC 2023 , Edited by admin on Fri Dec 15 16:14:54 UTC 2023
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92024769
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140503
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1332-58-7
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24H4NWX5CO
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m6600
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104100
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D007616
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24H4NWX5CO
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Kaolinite
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DTXSID6049640
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SUB14294MIG
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DB01575
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C80285
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KAOLIN
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PRIMARY | Description: A white or greyish white, unctuous powder, free from gritty particles; odour, clay-like. Solubility: Practically insoluble in water and in organic solvents; insoluble in mineral acids and solutions of alkali hydroxides. Category: Tablet and capsule diluent; suspending agent. Storage: Kaolin should be kept in a well-closed container. Labeling: The designation on the container of Kaolin should state whether it is intended for internal use. Additional information: Attention should be paid to the microbiological quality, since Kaolin is of mineral origin. Definition: Kaolin is a purified, natural hydrated aluminium silicate, the composition of which is variable. | ||
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100000088207
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630
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C45678
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CONCEPT | Industrial Aid |
ACTIVE MOIETY
