Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C20H25N3O4.C4H6O5 |
| Molecular Weight | 505.5176 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CC(O)=O)C(O)=O.COC1=C(C=CC2=C1N(C=C(C(O)=O)C2=O)C3CC3)N4C[C@@H](C)C[C@H](N)C4
InChI
InChIKey=YMVJINCWEIPOFL-FXMYHANSSA-N
InChI=1S/C20H25N3O4.C4H6O5/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26;5-2(4(8)9)1-3(6)7/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26);2,5H,1H2,(H,6,7)(H,8,9)/t11-,12-;/m0./s1
Nemonoxacin is a non-fluorinated quinolone antibiotic in clinical development in an oral and intravenous formulation. It exhibits potent antibacterial activities against Gram-positive, Gram-negative, and atypical pathogens, especially methicillin-resistant Staphylococcus aureus. The molecule inhibits bacterial DNA synthesis by forming a ternary complex with a DNA molecule and gyrase and topoisomerase IV enzymes, thus blocking bacterial DNA supercoiling. Nemonoxacin is developed by TaiGen Biotechnology Company and has reached worldwide approval in 2014 and is marketed under the name Taigexyn®.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. | 2010-11 |
|
| In vitro activity of nemonoxacin, tigecycline, and other antimicrobial agents against Helicobacter pylori isolates in Taiwan, 1998-2007. | 2010-11 |
|
| Gateways to clinical trials. | 2010-06 |
|
| In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan. | 2009-12 |
|
| Comparative in vitro activities of the new quinolone nemonoxacin (TG-873870), gemifloxacin and other quinolones against clinical isolates of Mycobacterium tuberculosis. | 2009-08 |
|
| Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species. | 2009-07 |
|
| New antibiotics for antibiotic-resistant bacteria. | 2009-05-28 |
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300000038179
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ACTIVE MOIETY
SUBSTANCE RECORD
