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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18ClNO5
Molecular Weight 363.792
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETOFIBRATE

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OCCOC(=O)C2=CN=CC=C2

InChI

InChIKey=XXRVYAFBUDSLJX-UHFFFAOYSA-N
InChI=1S/C18H18ClNO5/c1-18(2,25-15-7-5-14(19)6-8-15)17(22)24-11-10-23-16(21)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3

HIDE SMILES / InChI

Description

Etofibrate is an ethylene glycol diester of clofibrate and nicotinic acid. The drug was used under the names Tricerol and Lipo-Merz, among the others, for the treatment of severe hypertriglyceridemia and mixed hyperlipidemia. The mechanism of etofibrate action implies activation of PPAR-alpha receptors.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LIPO-MERZ RETARD
Primary
LIPO-MERZ RETARD

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The recommended dose is 1 sustained-release capsule (500 mg) once daily. In special cases, up to 2 sustained-release capsules can be prescribed.
Route of Administration: Oral
In Vitro Use Guide
Unknown