S-ETHYLISOTHIOUREA

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H8N2S
Molecular Weight	104.174
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCSC(N)=N

InChI

InChIKey=VFIZBHJTOHUOEK-UHFFFAOYSA-N

InChI=1S/C3H8N2S/c1-2-6-3(4)5/h2H2,1H3,(H3,4,5)

HIDE SMILES / InChI

Description
Sources: http://new.trioxbio.com/ | https://www.ncbi.nlm.nih.gov/pubmed/22144183

TrioxBio's API, S-ethylisothiouronium diethylphosphate, MTR-104 (MTR- 105), is a nitric oxide synthase (NOS) inhibitor which blocks the production of nitric oxide, preventing the dilation of blood vessels and the other detrimental effects caused by excessive NOS activity. MTR-105, a fast-acting synthetic NOS inhibitor with rapid onset of action when administered parenterally, has been effective in alleviating hypotension experimentally and in several observational studies while reducing NO production. MTR-105 is registered and approved for clinical use in the Republic of Moldova where data have been collected from 434 patients exposed to the drug in pre- and postapproval clinical investigations.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Nitric oxide synthase, inducible 50 Target ID: CHEMBL4481 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7523409 \| https://www.ncbi.nlm.nih.gov/pubmed/19819972 \| https://www.ncbi.nlm.nih.gov/pubmed/10074942	Inhibitor 8297	17.0 nM [Ki]
Nitric-oxide synthase, endothelial 19 Target ID: CHEMBL4803 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7523409 \| https://www.ncbi.nlm.nih.gov/pubmed/10074942	Inhibitor 8297	36.0 nM [Ki]
Nitric-oxide synthase, brain 24 Target ID: CHEMBL3568 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7523409	Inhibitor 8297	29.0 nM [Ki]

PubMed

Title	Date	PubMed
L-arginine increases dopamine transporter activity in rat striatum via a nitric oxide synthase-dependent mechanism.	2004 Dec 1	15452864
Contribution of nitric oxide produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in streptozotocin-diabetic rats.	2004 Jan	14707030
Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: biochemical characterization and link to cGMP pathways.	2005 Apr	15811509
[The estimation of the nitric oxide role in the aggravation of combined radiation-thermal injuries].	2005 May-Jun	16080623
Nitric Oxide does not mediate Atrogin-1/MAFbx upregulation by inflammatory mediators.	2008	21614134
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats.	2008 Aug 20	18598693
Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.	2008 Sep 5	18606809
Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway.	2009 Nov	19819972
Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa.	2012 Mar 8	22144183
Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs.	2012 May	22050008
Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction.	2014 Jan	24346018

Patents

Sample Use Guides

In Vivo Use Guide

Thirty-six patients with an ejection fraction >50% undergoing open-heart surgery were randomly assigned to either 50 ug kg(-1) min(-1) MTR-105 (M50, n = 12), 10 ug kg(-1) min(-1) MTR-105 (M10, n = 12) or buffered phosphate solution (placebo control, n = 12). Intravenous MTR-105 was administered continuously starting at aortic cross-clamp removal and ending 6 h later. MTR-105 doses were associated with an immediate increase in systemic blood pressure (16%) and systemic vascular resistance and a decrease in cardiac index.

Route of Administration: Intravenous

Name

Type

Language

S-ETHYLISOTHIOUREA

Systematic Name

English

2-ETHYL-2-THIOPSEUDOUREA

Systematic Name

English

CARBAMIMIDOTHIOIC ACID, ETHYL ESTER

Systematic Name

English

S-ETHYLISOTHIOURONIUM

Common Name

English

ETHYRON

Common Name

English

Code System Code Type Description

DRUG BANK

DB02234