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Description

Capreomycin is an antibiotic, which is used in combination other antituberculosis drugs fro the treatment of pulmonary infections caused by capreomycin-susceptible strains of M. tuberculosis when the primary agents (isoniazid, rifampin, ethambutol, aminosalicylic acid, and streptomycin) have been ineffective or cannot be used because of toxicity or the presence of resistant tubercle bacilli. Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins.

CNS Activity

Approval Year

1971
86
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
CAPASTAT SULFATE

Approved Use

Capastat Sulfate, which is to be used concomitantly with other appropriate antituberculosis agents, is indicated in pulmonary infections caused by capreomycin-susceptible strains of M. tuberculosis when the primary agents (isoniazid, rifampin, ethambutol, aminosalicylic acid, and streptomycin) have been ineffective or cannot be used because of toxicity or the presence of resistant tubercle bacilli. Susceptibility studies should be performed to determine the presence of a capreomycin-susceptible strain of M. tuberculosis.

Launch Date

4.4668801E10
PubMed

PubMed

TitleDatePubMed
Capreomycin is active against non-replicating M. tuberculosis.
2005 Apr 1
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs.
2006 Jul 21
Patents

Patents

EP0065884
2
EP0173990
2
EP0315300
2
EP0475160
2
EP0786999
2

Sample Use Guides

In Vivo Use Guide
Intravenously: Capastat Sulfate (Capreomycin for Injection) should be diluted in 100 mL of 0.9% Sodium Chloride Injection and administered over 60 minutes. Intramuscularly — Reconstituted Capastat Sulfate should be given by deep intramuscular injection into a large muscle mass, since superficial injection may be associated with increased pain and the development of sterile abscesses. For administration of a 1-g dose, the entire contents of the vial should be given. For doses lower than 1 g, the following dilution table may be used.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
CAPREOMYCIN
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
CAPREOMYCIN [HSDB]
Common Name English
CAPREOMICIN
Common Name English
Capreomycin [WHO-DD]
Common Name English
CAPREOMYCIN [MI]
Common Name English
CAPOSTATIN
Common Name English
capreomycin [INN]
Common Name English
CAPASTAT
Brand Name English
CAPREOMYCIN [VANDF]
Common Name English
CAPROMYCIN
Common Name English
Classification Tree Code System Code
WHO-VATC QJ04AB30
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NDF-RT N0000175483
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NCI_THESAURUS C280
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LIVERTOX NBK548641
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NCI_THESAURUS C2363
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WHO-ATC J04AB30
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WHO-ESSENTIAL MEDICINES LIST 6.2.4
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Code System Code Type Description
MERCK INDEX
m3029
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PRIMARY Merck Index
ChEMBL
CHEMBL2221250
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PRIMARY
RXCUI
78903
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PRIMARY RxNorm
EVMPD
SUB01028MIG
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PRIMARY
DRUG BANK
DB00314
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PRIMARY
HSDB
3211
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PRIMARY
WIKIPEDIA
CAPREOMYCIN
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PRIMARY
DRUG CENTRAL
3063
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PRIMARY
EPA CompTox
DTXSID8040989
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PRIMARY
INN
1145
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PRIMARY
NCI_THESAURUS
C72607
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PRIMARY
MESH
D002207
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PRIMARY
LACTMED
Capreomycin
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PRIMARY
CAS
11003-38-6
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PRIMARY
FDA UNII
232HYX66HC
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PRIMARY
All of the following components must be present:
Structure of CAPREOMYCIN IB
Structure of CAPREOMYCIN IIA
Structure of CAPREOMYCIN IA
Structure of CAPREOMYCIN IIB
ACTIVE MOIETY
CAPREOMYCIN
Definition References
NIH
NCATS
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