Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C49H68N18O9S2.3C2H4O2 |
| Molecular Weight | 1297.465 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)=O.CC(O)=O.CC(O)=O.C[C@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CN=CN5)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
InChI
InChIKey=PILXXDANZBQUJH-AKVBKPKISA-N
InChI=1S/C49H68N18O9S2.3C2H4O2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52;3*1-2(3)4/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57);3*1H3,(H,3,4)/t26-,33+,34+,35-,36+,37+,38+,39+;;;/m1.../s1
Setmelanotide (RM-493), is an investigational, first-in-class melanocortin-4 receptor (MC4R) agonist in development for the treatment of rare genetic disorders of obesity. Setmelanotide is thought to activate the MC4R, part of a key biological pathway in humans that regulates weight by increasing energy expenditure and reducing appetite. Variants in genes within the MC4 pathway are associated with unrelenting hunger, known as hyperphagia, and severe, early-onset obesity. Setmelanotide is a potential replacement therapy that may restore lost activity in the MC4 pathway, reestablishing weight and appetite control in patients with these rare genetic disorders.
Originator
Approval Year
Sample Use Guides
Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) patients with moderate to severe obesity:
Subcutaneous injection, 3 mg, daily
Route of Administration:
Other
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224I1W20I7
Created by
admin on Sat Dec 16 16:05:16 GMT 2023 , Edited by admin on Sat Dec 16 16:05:16 GMT 2023
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PRIMARY | |||
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1504602-49-6
Created by
admin on Sat Dec 16 16:05:16 GMT 2023 , Edited by admin on Sat Dec 16 16:05:16 GMT 2023
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NON-SPECIFIC STOICHIOMETRY | |||
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2469248
Created by
admin on Sat Dec 16 16:05:16 GMT 2023 , Edited by admin on Sat Dec 16 16:05:16 GMT 2023
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PRIMARY | |||
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155491122
Created by
admin on Sat Dec 16 16:05:16 GMT 2023 , Edited by admin on Sat Dec 16 16:05:16 GMT 2023
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PRIMARY | PUBCHEM |
ACTIVE MOIETY
SUBSTANCE RECORD
