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Details

Stereochemistry ABSOLUTE
Molecular Formula C41H76N2O15
Molecular Weight 837.0465
Optical Activity UNSPECIFIED
Defined Stereocenters 18 / 18
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ROXITHROMYCIN

SMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)\C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

InChIKey=RXZBMPWDPOLZGW-XMRMVWPWSA-N
InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1

HIDE SMILES / InChI

Description

Roxithromycin is a semi-synthetic macrolide antibiotic, which was developed by Roussel Uclaf and is available in Australia. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. It can treat respiratory tract, urinary and soft tissue infections.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
ROXITHROMYCIN SANDOZ
Curative
ROXITHROMYCIN SANDOZ
Curative
ROXITHROMYCIN SANDOZ
Curative
ROXITHROMYCIN SANDOZ
Curative
ROXITHROMYCIN SANDOZ

PubMed

Sample Use Guides

In Vivo Use Guide
The recommended dosage for adults is 300mg per day. You may take this according to one of the following dosage regimens: one 300mg tablet once a day, or one 150mg tablet twice a day, or two 150 mg tablets once a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown