Details
Stereochemistry | ACHIRAL |
Molecular Formula | Sm |
Molecular Weight | 152.9221 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 3 |
SHOW SMILES / InChI
SMILES
[153Sm+3]
InChI
InChIKey=DOSGOCSVHPUUIA-AKLPVKDBSA-N
InChI=1S/Sm/q+3/i1+3
Samarium SM-153 lexidronam is a chelated complex of a radioisotope of the element samarium with ethylenediamine tetra(methylene phosphonic acid) (EDTMP). Samarium Sm-153 EDTMP has an affinity for bone and concentrates in areas of bone turnover in association with hydroxyapatite. In clinical studies employing planar imaging techniques, more Samarium (153Sm) lexidronam accumulates in osteoblastic lesions than in normal bone with a lesion-to-normal bone ratio of approximately 5. It is indicated for the relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan. It should not be given concurrently with chemotherapy or external beam radiation therapy unless the benefit outweighs the risks. The most common adverse events are: nausea and vomiting, hemoglobin decrease, myasthenia, paresthesia, thrombocytopenia and abdominal pain.
Approval Year
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90479421
Created by
admin on Sat Dec 16 08:45:14 UTC 2023 , Edited by admin on Sat Dec 16 08:45:14 UTC 2023
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1261243-51-9
Created by
admin on Sat Dec 16 08:45:14 UTC 2023 , Edited by admin on Sat Dec 16 08:45:14 UTC 2023
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2128O9F90Y
Created by
admin on Sat Dec 16 08:45:14 UTC 2023 , Edited by admin on Sat Dec 16 08:45:14 UTC 2023
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PRIMARY |
ACTIVE MOIETY