AMINOPENTAMIDE SULFATE

First approved in 1953

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2O.H2O4S
Molecular Weight	394.485
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.CC(CC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C

InChI

InChIKey=GEKOQGPXZRQQHJ-UHFFFAOYSA-N

InChI=1S/C19H24N2O.H2O4S/c1-15(21(2)3)14-19(18(20)22,16-10-6-4-7-11-16)17-12-8-5-9-13-17;1-5(2,3)4/h4-13,15H,14H2,1-3H3,(H2,20,22);(H2,1,2,3,4)

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/pro/centrine.html | https://www.law.cornell.edu/cfr/text/21/522.62 | http://www.petplace.com/article/drug-library/library/prescription/aminopentamide-centrine

Aminopentamide is a potent antispasmodic agent. As a cholinergic blocking agent for smooth muscle, its action is similar to atropine. Aminopentamide hydrogen sulfate is marketed under the brand name Centrine indicated in the treatment of acute abdominal visceral spasm, pylorospasm or hypertrophic gastritis and associated nausea, vomiting and/or diarrhea of the dogs and cats. Centrine effectively reduces the tone and amplitude of colonic contractions to a greater degree and for a more extended period than does atropine. Centrine effects a reduction in gastric secretion, a decrease in gastric acidity and a marked decrease in gastric motility. Aminopentamide is a nonselective muscarinic cholinergic .

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: https://www.drugs.com/pro/centrine.html \| http://veterinarycalendar.dvm360.com/antiemetic-therapy-dogs-and-cats-new-versus-old-proceedings \| https://books.google.ru/books?id=8iwym8Q5XQ8C&pg=PA484&lpg=PA484&dq=aminopentamide retrieved from Canine and Feline Gastroenterology - E-Book By Robert J. Washabau, Michael J. Day, p.484	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertrophic gastritis 6 Sources: https://www.drugs.com/pro/centrine.html	Primary		Approved 8429	Centrine Approved Use Centrine is indicated in the treatment of acute abdominal visceral spasm, pylorospasm or hypertrophic gastritis and associated nausea, vomiting and/or diarrhea. Launch Date 1970

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY562581	https://www.001chemical.com/chem/60-46-8
AK Scientific, Inc. (AKSCI)	X4884	http://www.aksci.com/item_detail.php?cat=X4884
Alfa Chemistry	60-46-8	https://www.alfa-chemistry.com/aminopentamide-sulfate-200-mg-cas-60-46-8-item-292915.htm
Alichem	19126227	http://www.alichem.com/en/products/60-46-8.html
Aurora Fine Chemicals LLC	A17.946.078	http://online.aurorafinechemicals.com/info?ID=A17.946.078
BLD Pharm	BD114001	http://www.bldpharm.com/products/60-46-8.html
BioChemPartner	BCP32413	http://www.biochempartner.com/60-46-8-BCP32413
ChemMol	99117809	http://www.chemmol.com/chemmol/99117809.html
Chemspace	CSSB00020675437	https://chem-space.com/CSSB00020675437
LGC Standards	DRE-C10209400	https://www.lgcstandards.com/US/en/p/DRE-C10209400
Molcore	MC562581	https://www.molcore.com/product/60-46-8
Sigma-Aldrich	PH004881_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/ph004881
Smolecule	S571745	https://www.smolecule.com/products/s571745
abcr GmbH	AB511594	http://www.abcr.com/shop/en/AB511594
eNovation Chemicals	D131710	https://www.enovationchem.com/ProductDetails.asp?ProductID=D131710

PubMed

Title	Date	PubMed
The pharmacological activity of DL-alpha, alpha-diphenyl, gamma-dimethylaminovaleramide (centrine).	1954 Jan	13118479
Some aspects of the pharmacology and clinical application of a parasympatholytic agent, aminopentamide.	1956 Sep 1	13358891
[Broncholytic effect of a new synthetic drugs: aminopentamide].	1957 Jun	13499735

Patents

Sample Use Guides

In Vivo Use Guide

Dogs and cats: Administer by subcutaneous or intramuscular injection every 8 to 12 hours as follows: For animals weighing up to 10 pounds (lbs): 0.1 mg; For animals weighing 11 to 20 lbs: 0.2 mg; For animals weighing 21 to 50 lbs: 0.3 mg; For animals weighing 51 to 100 lbs: 0.4 mg; For animals weighing over 100 lbs: 0.5 mg. Dosage may be gradually increased up to a maximum of five times the suggested dosage. Following parenteral use, dosage may be continued by oral administration of tablets.

Route of Administration: Other

In Vitro Use Guide

A concentration of 0.00005 mg of Aminopentamide per ml of bath fluid was found to reduce the frequency of guinea pig ureteral contractions and a concentration of 0.005 mg/ml virtually stopped contractions.

Name

Type

Language

AMINOPENTAMIDE SULFATE

Common Name

English

AMINOPENTAMIDE ACID SULFATE, DL-

Common Name

English

AMINOPENTAMIDE HYDROGEN SULFATE

Common Name

English

DIMEVAMIDE SULFATE [MART.]

Common Name

English

4-(DIMETHYLAMINO)-2,2-DIPHENYLVALERAMIDE HYDROGEN SULFATE

Systematic Name

English

AMINOPENTAMIDE HYDROGEN SULFATE [GREEN BOOK]

Common Name

English

AMINOPENTAMIDE SULFATE [USP MONOGRAPH]

Common Name

English

AMINOPENTAMIDE SULFATE [USP-RS]

Common Name

English

VALERAMIDE, 4-(DIMETHYLAMINO)-2,2-DIPHENYL-, SULPHATE (1:1)

Systematic Name

English

AMINOPENTAMIDE SULPHATE

Common Name

English

.ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYLBENZENEACETAMIDE SULFATE

Systematic Name

English

VALERAMIDE, 4-(DIMETHYLAMINO)-2,2-DIPHENYL-, SULFATE (1:1)

Systematic Name

English

.ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYLBENZENEACETAMIDE SULPHATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704