Stereochemistry | ACHIRAL |
Molecular Formula | C13H10O5 |
Molecular Weight | 246.2155 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2OC=CC2=C(OC)C3=C1OC(=O)C=C3
InChI
InChIKey=DFMAXQKDIGCMTL-UHFFFAOYSA-N
InChI=1S/C13H10O5/c1-15-10-7-3-4-9(14)18-12(7)13(16-2)11-8(10)5-6-17-11/h3-6H,1-2H3
Isopimpinellin is a natural product synthesized by Umbelliferae (or Apiaceae), also known as the carrot or parsley family. It can be found in celery, garden angelica, parsnip, fruits and in the rind and pulp of limes. There have been several studies looking into the effects of Isopimpinellin and other so-called naturally occurring coumarins (such as bergamottin and Imperatorin) as anticarcinogens.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
RAW264.7 cells were seeded in 96-well plates and maintained in DMEM supplemented with 5% FBS, 100 U/ml penicillin, and 100 mg/ml streptomycin. After incubation at 37 °C for 24 h, compounds were added into the media and incubated for 4 h. Then LPS (1 mg/ml) was added and co-incubated for another 24 h. After that, the supernatant of the media was mixed with an equal volume of Griess reagent. Nitrite production was determined by measuring the optical density at 540 nm.