Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H2Cl4I4O5.2K |
Molecular Weight | 1049.853 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].[K+].[O-]C(=O)C1=C(C(Cl)=C(Cl)C(Cl)=C1Cl)C2=C3C=C(I)C(=O)C(I)=C3OC4=C2C=C(I)C([O-])=C4I
InChI
InChIKey=AZJPTIGZZTZIDR-UHFFFAOYSA-L
InChI=1S/C20H4Cl4I4O5.2K/c21-10-8(9(20(31)32)11(22)13(24)12(10)23)7-3-1-5(25)16(29)14(27)18(3)33-19-4(7)2-6(26)17(30)15(19)28;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11931626 | https://www.ncbi.nlm.nih.gov/pubmed/11695899 | https://www.ncbi.nlm.nih.gov/pubmed/10704233 | http://pubs.acs.org/doi/abs/10.1021/ja00332a021 | https://www.ncbi.nlm.nih.gov/pubmed/24405273
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11931626 | https://www.ncbi.nlm.nih.gov/pubmed/11695899 | https://www.ncbi.nlm.nih.gov/pubmed/10704233 | http://pubs.acs.org/doi/abs/10.1021/ja00332a021 | https://www.ncbi.nlm.nih.gov/pubmed/24405273
Rose Bengal lactone is a polyhalogenated derivative of Fluorescein. Rose Bengal lactone is a dye compound described to produce cell membrane damage. Rose Bengal lactone and other Fluorescein derivatives are also described to modulate the function of ATP-sensitive K+ channels. Rose bengal lactone reacts readily with bases so treatment with triethylamine immediately yields the Rose Bengal salt.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2522 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11931626 |
80.0 µM [IC50] | ||
Target ID: CHEMBL1981 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11695899 |
20.0 µM [Kd] | ||
Target ID: CHEMBL2026 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11931626 |
16.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11931626
Rose Bengal lactone at 20 times the IC50 or DMSO alone was incubated with 10 nM beta-lactamase in 10 kDa dialysis tubing. Ten milliliters of this solution was dialyzed at room temperature against three 1 L volumes of 50 mM KPi buffer, pH 7.0, exchanged hourly. After dialysis, the incubation solution was diluted 10-fold and assayed for beta-lactamase activity against 100 mkM cephalothin.
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SUB15148MIG
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DB11182
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10463
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9471
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24545-87-7
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1ZPG1ELY14
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m9663
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DTXSID00110057
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25473
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Rose bengal
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4637
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632-68-8
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100000078646
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211-182-8
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52261
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ACTIVE MOIETY
SUBSTANCE RECORD