SULFIRAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H20N2S3
Molecular Weight	264.474
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SULFIRAM

Structure Search

SMILES

CCN(CC)C(=S)SC(=S)N(CC)CC

InChI

InChIKey=CTPKSRZFJSJGML-UHFFFAOYSA-N

InChI=1S/C10H20N2S3/c1-5-11(6-2)9(13)15-10(14)12(7-3)8-4/h5-8H2,1-4H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11988682 | https://www.ncbi.nlm.nih.gov/pubmed/7986203 | https://www.ncbi.nlm.nih.gov/pubmed/7177842

Sulfiram (also known as monosulfiram) is a sulfide derivative patented by L. Givaudan & Cie. S. A. as effective anti-parasitic medicine used for the treatment and prevention of scabies and other skin related problems like itching, skin irritation, and inflammation. Sulfiram is a very weak inhibitor of aldehyde dehydrogenase. Sulfiram is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate. Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Aldehyde dehydrogenase 8 Target ID: CHEMBL1935 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7905136	Inhibitor 8297

PubMed

PubMed

Title	Date	PubMed
Diagnosis and treatment of scabies in 2002: rapid diagnosis and proper management limit the risk of spread.	2002 Oct	12378748
Current treatments for scabies.	2003 Apr	12667233

Patents

Patents

Name

Type

Language

SULFIRAM

Official Name

English

sulfiram [INN]

Common Name

English

SULFIRAM [MART.]

Common Name

English

TETMOSOL

Brand Name

English

SULFIRAME

Common Name

English

MONOSULFIRAM

Common Name

English

TETRAETHYLTHIODICARBONIC DIAMIDE ((((C(SUB 2)H(SUB 5))(SUB 2)N)C(S))(SUB 2)S)

Common Name

English

NSC-36731

Code

English

SULFIRAM [MI]

Common Name

English

Sulfiram [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1697

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

NCI_THESAURUS

C471

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

WHO-VATC

QS02QA02

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

Code System Code Type Description

EVMPD

SUB10738MIG

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

EPA CompTox

DTXSID5058222

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

ALANWOOD

sulfiram

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

INN

4006

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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CAS

95-05-6

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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RXCUI

30206

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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RxNorm

WIKIPEDIA

Sulfiram

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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NCI_THESAURUS

C66572

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

ECHA (EC/EINECS)

202-387-3

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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FDA UNII

1XHL4Q8P7Y

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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DRUG CENTRAL

3569

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

SMS_ID

100000083766

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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PUBCHEM

7215

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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MESH

C009822

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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ChEMBL

CHEMBL2004297

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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MERCK INDEX

m10350

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

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Merck Index

NSC

36731

Created by admin on Fri Dec 15 15:43:02 GMT 2023 , Edited by admin on Fri Dec 15 15:43:02 GMT 2023

PRIMARY

ACTIVE MOIETY


					1XHL4Q8P7Y

SULFIRAM