VALDETAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H17NO
Molecular Weight	155.2374
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

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Structure Search

SMILES

CCC(CC)(CC=C)C(N)=O

InChI

InChIKey=LOMDVEFCNVDZMZ-UHFFFAOYSA-N

InChI=1S/C9H17NO/c1-4-7-9(5-2,6-3)8(10)11/h4H,1,5-7H2,2-3H3,(H2,10,11)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/923433 | https://www.drugfuture.com/chemdata/valdetamide.html

Valdetamide (Novonal), a sedative/hypnotic dispensed without medical prescription in West Germany. It is quickly absorbed after oral intake, with a blood half-life of 6-11 hours, most of it being excreted by the kidneys after metabolic degradation. Analysis of 23 cases of Novonal intoxication revealed that cardiac arrhythmias, hypotension and respiratory depression may occur with 6 g Novonal (contained in a pocket of 20 tablets) and must thus be rated as potentially lethal.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

The application of 0.15 and 0.3% of diethylallylacetamide (Valdetamide, DA) in the drinking water to rats during 10 days increased the relative liver weight, the yield of hepatic microsomes, and cytochromes P-450 and b5. Single s.c. doses of 400 mg DA per kg reduced cytochrome P-450 concentrations in the hepatic endoplasmic reticulum of rats.

Route of Administration: Other

In Vitro Use Guide

The aerobic incubation of 0.1 mM Valdetamide with rabbit hepatic microsomes in the presence of NADPH produced 50% destruction of cytochrome P-450 within 1 h.

Name

Type

Language

VALDETAMIDE

Official Name

English

Valdetamide [WHO-DD]

Common Name

English

valdetamide [INN]

Common Name

English

VALDETAMIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756