Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H17NO |
Molecular Weight | 155.2374 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(CC)(CC=C)C(N)=O
InChI
InChIKey=LOMDVEFCNVDZMZ-UHFFFAOYSA-N
InChI=1S/C9H17NO/c1-4-7-9(5-2,6-3)8(10)11/h4H,1,5-7H2,2-3H3,(H2,10,11)
Valdetamide (Novonal), a sedative/hypnotic dispensed without medical prescription in West Germany. It is quickly absorbed after oral intake, with a blood half-life of 6-11 hours, most of it being excreted by the kidneys after metabolic degradation. Analysis of 23 cases of Novonal intoxication revealed that cardiac arrhythmias, hypotension and respiratory depression may occur with 6 g Novonal (contained in a pocket of 20 tablets) and must thus be rated as potentially lethal.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/485854
The application of 0.15 and 0.3% of diethylallylacetamide (Valdetamide, DA) in the drinking water to rats during 10 days increased the relative liver weight, the yield of hepatic microsomes, and cytochromes P-450 and b5. Single s.c. doses of 400 mg DA per kg reduced cytochrome P-450 concentrations in the hepatic endoplasmic reticulum of rats.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/485854
The aerobic incubation of 0.1 mM Valdetamide with rabbit hepatic microsomes in the presence of NADPH produced 50% destruction of cytochrome P-450 within 1 h.
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NCI_THESAURUS |
C29756
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C74376
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208-143-2
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m11357
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SUB00005MIG
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ACTIVE MOIETY