VALDETAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H17NO
Molecular Weight	155.2374
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(CC)(CC=C)C(N)=O

InChI

InChIKey=LOMDVEFCNVDZMZ-UHFFFAOYSA-N

InChI=1S/C9H17NO/c1-4-7-9(5-2,6-3)8(10)11/h4H,1,5-7H2,2-3H3,(H2,10,11)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/923433 | https://www.drugfuture.com/chemdata/valdetamide.html

Valdetamide (Novonal), a sedative/hypnotic dispensed without medical prescription in West Germany. It is quickly absorbed after oral intake, with a blood half-life of 6-11 hours, most of it being excreted by the kidneys after metabolic degradation. Analysis of 23 cases of Novonal intoxication revealed that cardiac arrhythmias, hypotension and respiratory depression may occur with 6 g Novonal (contained in a pocket of 20 tablets) and must thus be rated as potentially lethal.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Detection and quantitative estimation of 2,2-diethyl-4-pentenamide in a fatal case of poisoning (author's transl)].	1977 Jul 5	18861
2, 2-Diethyl-4-pentenamide, a sedative of new importance.	1979	505965
The allylisopropylacetamide and novonal prosthetic heme adducts.	1984 Mar	6700576

Patents

Sample Use Guides

In Vivo Use Guide

The application of 0.15 and 0.3% of diethylallylacetamide (Valdetamide, DA) in the drinking water to rats during 10 days increased the relative liver weight, the yield of hepatic microsomes, and cytochromes P-450 and b5. Single s.c. doses of 400 mg DA per kg reduced cytochrome P-450 concentrations in the hepatic endoplasmic reticulum of rats.

Route of Administration: Other

In Vitro Use Guide

The aerobic incubation of 0.1 mM Valdetamide with rabbit hepatic microsomes in the presence of NADPH produced 50% destruction of cytochrome P-450 within 1 h.

Name

Type

Language

VALDETAMIDE

Official Name

English

Valdetamide [WHO-DD]

Common Name

English

valdetamide [INN]

Common Name

English

VALDETAMIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756